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Association of complement 5 genetic polymorphism with renal allograft outcomes : 혈청보체인자 5의 유전적 다형성과 신장이식 후 이식신 성적의 연관성
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 안규리 | - |
dc.contributor.author | 정종철 | - |
dc.date.accessioned | 2017-07-19T10:20:30Z | - |
dc.date.available | 2017-07-19T10:20:30Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.other | 000000010417 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132583 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과 면역학 전공, 2013. 2. 안규리. | - |
dc.description.abstract | Background: Complements play important roles in both rejection and ischemia-reperfusion injury after transplantation. Complement 5 (C5) is a pivotal complement, which initiates the assembly of the membrane attack complex, and mediates chemotaxis of various immune cells. I investigated the impacts of genetic variations in C5 and its receptor (C5aR) of both recipients and donors on renal allograft outcomes.
Materials and Methods: Seven single nucleotide polymorphisms (SNPs) in C5 (rs12237774 | - |
dc.description.abstract | rs2159776 | - |
dc.description.abstract | rs17611 | - |
dc.description.abstract | rs25681 | - |
dc.description.abstract | rs2241004 | - |
dc.description.abstract | rs10985126 | - |
dc.description.abstract | rs10818500) and one SNP (rs10404456) in the C5aR gene were genotyped in 191 recipient-donor pairs. The association of the polymorphisms with allograft outcomes was determined.
Results: Three C5 SNPs (rs2159776 | - |
dc.description.abstract | rs25681) in recipients had a tendency toward a reduced glomerular filtration rate (eGFR) at one year after transplantation. There were four haplotypes in the H2 linkage disequilibrium block, which was formed by four SNPs (rs2159776 | - |
dc.description.abstract | rs2241004). The GGCG haplotype in both recipients and donors was associated with lower GFR at one year (60.9±15.9 vs. 66.4±15.5 ml/minute/1.73m2, P=0.020 | - |
dc.description.abstract | 60.6±15.3 vs. 66.2±15.8 ml/minute/1.73m2, P=0.017). The association was sustained over 7 years after transplantation (P=0.015 in recipients | - |
dc.description.abstract | P=0.039 in donors). The presence of the GGCG haplotype in recipients was associated with poorer graft survival (log-rank test, P=0.024). However, C5 polymorphisms were not correlated with serum C5 level. C5aR polymorphism had no significant impact on the allograft outcomes.
Conclusions: The GGCG haplotype of complement 5 in both recipients and donors was associated with lower renal allograft function. | - |
dc.description.tableofcontents | Abstract i
Contents iv List of Tables and Figures vi List of Abbreviations ix Introduction 1 Materials and Methods 4 Study population 4 Genotyping 4 Clinical data analysis 7 Determination of serum C5 level 7 Statistical analysis 8 Results 10 Baseline clinical characteristics of study population 10 Genotyping and construction of LD blocks 11 Association of C5/C5aR genotypes of recipients/donors with acute rejection 13 Association of C5/C5aR genotypes/haplotypes of recipients/donors with graft function 13 Association of C5/C5aR haplotypes of recipients/donors with graft survival 30 Association of C5/C5aR haplotypes with serum C5 level 31 Discussion 34 Conclusions 40 References 41 요약 (국문 초록) 48 | - |
dc.format | application/pdf | - |
dc.format.extent | 682500 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | complement | - |
dc.subject | kidney transplantation | - |
dc.subject | polymorphism | - |
dc.subject | transplantation outcome | - |
dc.subject.ddc | 610 | - |
dc.title | Association of complement 5 genetic polymorphism with renal allograft outcomes | - |
dc.title.alternative | 혈청보체인자 5의 유전적 다형성과 신장이식 후 이식신 성적의 연관성 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Jong Cheol Jeong | - |
dc.description.degree | Master | - |
dc.citation.pages | ix, 50 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2013-02 | - |
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