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The Effect of Substance P on Skin Flap Survival in Rats
DC Field | Value | Language |
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dc.contributor.advisor | 민경원 | - |
dc.contributor.author | ZHENYU WU | - |
dc.date.accessioned | 2017-07-19T10:20:38Z | - |
dc.date.available | 2017-07-19T10:20:38Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.other | 000000010457 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132585 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과 성형외과학 전공, 2013. 2. 민경원. | - |
dc.description.abstract | Introduction: Skin flap necrosis is a challenging problem in reconstructive surgery. Pharmacologic administration that increases skin flap survaival has been investigated extensively. It has been reported that substance P, a member of tachykinin family neuropetides, stimulates vessel growth in a variety of angiogenesis assays. The purpose of this study was to evaluate the effects of local administration of substance P on skin flap survival in rat model.
Materials and Methods: Twenty-four male Sprague-Dawley rats were randomly divided into two groups of twelve. Rats were anesthetized, and a skin flap, measuring 10 × 3 cm was designed on the rat dorsum. After local injections of 1ml substance P (100nmol) or normal saline (control) at the distal half, the skin flaps were elevated. Then the flaps were immediately sutured back in situ. 7 days after the flap elevation, survival rate of the flap was calculated and a histological examination was performed. Results: The mean survival rate of flaps in substance P administration group (80.4±7.0%) was significantly higher than that in control group (61.9±6.9%)(p<0.001). Histological observation of the flaps showed increase of vessel number in the group treated with substance P when compared with the control group. Conclusion: The results demonstrate that the use of local administration of substance P increases skin flap survival in rats by enhanced vessel number. -------------------------------- ----- Keywords: Substance P, Skin flap survival, Angiogenesis. Student number: 2011-23017 | - |
dc.description.tableofcontents | ABSTARCT
CONTENTS LIST OF FIGURES INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES ABSTRACT IN KOREAN | - |
dc.format | application/pdf | - |
dc.format.extent | 769957 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 610 | - |
dc.title | The Effect of Substance P on Skin Flap Survival in Rats | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | iv, 25 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2013-02 | - |
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