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Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance : 두경부 편평세포암종에서의 저산소성 신호표지자의 발현
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 권택균 | - |
dc.contributor.author | 최효근 | - |
dc.date.accessioned | 2017-07-19T10:21:42Z | - |
dc.date.available | 2017-07-19T10:21:42Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.other | 000000016595 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132608 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2014. 2. 권택균. | - |
dc.description.abstract | Background: Hypoxia is a consistent finding in fast-growing tumors | - |
dc.description.abstract | it contributes to tumor progression and therapeutic responses. We explored the expression of hypoxia-associated biomarkers in head and neck squamous cell carcinoma (HNSCC) to assess their relationship with clinical factors in HNSCC.
Materials and methods: In total, 90 patients with HNSCC were enrolled. Expression of HIF-1α, HSP70, HSP90, VEGF, IGF-1R, and P16 was investigated by immunohistochemistry. Their correlations with clinical factors, including location of primary sites, T stage, N stage, M stage, HPV status, primary treatment success/failure, recurrences, disease-free survival (DFS), and overall survival (OS), were analyzed. Results: HIF-1α, HPS70, HPS90, VEGF, and IGF-1R were positive in 33 of 89 (37.1%), 62 of 87 (71.3%), 83 of 89 (93.3%), 41 of 87 (47.1%), and 50 of 56 (89.3%) cases, respectively. Expression levels of some of these markers were correlated. High HIF-1α or HSP 70 correlated with poor DFS, and expression of HSP70 correlated with LN metastasis. HPV related carcinomas showed high HSP 70 and IGF-1R expression. Conclusions: Hypoxia-associated proteins were highly expressed and associated with aggressive clinical features in HNSCC. Expression of HIF-1α and/or HSP70 can be considered poor prognostic indicators in HNSCC. Our results suggest that hypoxic signaling is activated in HNSCC, especially in HPV-related tumors. | - |
dc.description.tableofcontents | Abstract -------------------------------------------------------------------------------------- 1
Table of Contents ----------------------------------------------------------------------------- 3 List of Tables and Figures ------------------------------------------------------------------- 4 List of Abbreviations-------------------------------------------------------------------------- 5 Introduction ---------------------------------------------------------------------------------- 6 Materials & Methods ------------------------------------------------------------------------- 7 Results -------------------------------------------------------------------------------------- 10 Discussion ---------------------------------------------------------------------------------- 13 Conclusions -------------------------------------------------------------------------------- 15 References ---------------------------------------------------------------------------------- 17 Korean Abstract ----------------------------------------------------------------------------- 33 | - |
dc.format | application/pdf | - |
dc.format.extent | 1098943 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 610 | - |
dc.title | Expression of hypoxic signaling markers in head and neck squamous cell carcinoma and its clinical significance | - |
dc.title.alternative | 두경부 편평세포암종에서의 저산소성 신호표지자의 발현 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Hyo Geun Choi | - |
dc.description.degree | Master | - |
dc.citation.pages | v, 29 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2014-02 | - |
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