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Eupatilin attenuates liver injury induced by methionine choline-deficient diet in mice : Eupatilin 이 methionine choline 결핍 식이에 의한 간 손상에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 윤정환 | - |
dc.contributor.author | 이동현 | - |
dc.date.accessioned | 2017-07-19T10:22:43Z | - |
dc.date.available | 2017-07-19T10:22:43Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.other | 000000016809 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132630 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2014. 2. 윤정환. | - |
dc.description.abstract | Introduction: The prevailing hypothesis in pathogenesis of nonalcoholic steatohepatitis (NASH) consists of two steps: excessive fat accumulation and hepatocyte injury by oxidative stress, abnormal cytokines, mitochondrial dysfunction, and/or endoplasmic reticulum (ER) stress. Eupatilin, a pharmacologically active ingredient found in Artemisia asiatica, has been established anti-oxidative, anti-inflammatory, and cytoprotective agents. In the present study, we evaluated whether eupatilin prevents the development of NASH in mice.
Methods: C57BL/6 mice were fed methionic choline-deficient (MCD) diet with or without eupatilin (50 or 100 mg/kg per body weight) for 8 weeks. The effects of eupatilin on the development and progression of NASH and underlying mechanism were studied. Results: Eupatilin attenuated the liver injury and contributed to histological improvements, including non-alcoholic fatty liver disease activity score (NAS) through suppression of hepatic inflammation, oxidative stress, and ER stress. However, pharmacological effect of eupatilin was not sufficient to reduce the NAS less than 5, which corresponded to NASH. Conclusions: Modulation of oxidative and ER stress by eupatilin was not sufficient to eradicate development of NASH. However, eupatilin ameliorated hepatocyte injury and NAS. Further studies are needed to maximize the preventative effects of eupatilin in NASH by dose increase or combination therapy. | - |
dc.description.tableofcontents | Abstract i
Contents iii List of tables iv List of figures v List of abbreviations and symbols vi Introduction 1 Materials and methods 3 Results 9 Discussion 20 References 23 요약 (국문 초록) 27 | - |
dc.format | application/pdf | - |
dc.format.extent | 1105207 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Nonalcoholic fatty liver disease | - |
dc.subject | Fatty liver | - |
dc.subject | Eupatilin | - |
dc.subject | Lipogenesis | - |
dc.subject | Endoplasmic reticulum stress | - |
dc.subject | Oxidative stress | - |
dc.subject.ddc | 610 | - |
dc.title | Eupatilin attenuates liver injury induced by methionine choline-deficient diet in mice | - |
dc.title.alternative | Eupatilin 이 methionine choline 결핍 식이에 의한 간 손상에 미치는 영향 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | vii, 28 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2014-02 | - |
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