S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) Theses (Master's Degree_의학과)
Ear Cartilage Regeneration: A Comparison of Free Perichondrial and Periosteal Grafts
- 의과대학 의학과
- Issue Date
- 서울대학교 대학원
- Ear Cartilage Regeneration
- 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2014. 2. 이윤호.
Ear cartilage is a good source for tissue support or augmentation in plastic and reconstructive surgery. However, the amount of ear cartilage is limited and excessive use of cartilage can cause deformation of the donor site. To minimize the loss of cartilage, the potential of periosteal chondrogenesis was investigated in an ear cartilage defect model.
Materials and Methods
Twelve New Zealand White rabbits were used in the present study. Four sections of ear cartilage defect were created on the ear of each rabbit bilaterally, between the central artery and marginal veins. Skin flaps measuring 12 × 12 mm2 were elevated and 10 × 10 mm2 auricular cartilage defects were created including the perichondrium. The defects were covered with perichondrium (group 1), periosteum taken from the calvarium (group 2), or periosteum taken from the tibia (group 3), whereas no coverage was made in a control group (group 4). All animals were sacrificed 6 weeks later, and the results were investigated both, macroscopically and microscopically.
Significant chondrogenesis occurred only in the perichondrial graft group, whereas osteogenesis, instead of chondrogenesis was seen in the periosteal graft groups. There was no statistical difference in the amount of osteogenesis or chondrogenesis between groups 2 and 3. Group 4 showed fibrous tissue accumulation in the defect area.
Periosteal grafts showed weak chondrogenic potential in an ear cartilage defect model
instead, they exhibited osteogenesis, and showed the same clinical activity irrespective of their embryological origin.