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Association of genetic risk factors for age-related macular degeneration with polypoidal choroidal vasculopathy and central serous chorioretinopathy : 결절 맥락막 혈관병증 및 중심성 장액맥락망막병증 환자에서 연령관련 황반변성의 관련 유전 위험인자의 분석
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 박규형 | - |
| dc.contributor.author | 유나경 | - |
| dc.date.accessioned | 2017-07-19T10:24:45Z | - |
| dc.date.available | 2017-07-19T10:24:45Z | - |
| dc.date.issued | 2014-02 | - |
| dc.identifier.other | 000000017638 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/132671 | - |
| dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2014. 2. 박규형. | - |
| dc.description.abstract | Purpose: To investigate the association of known genetic risk factors for age-related macular degeneration (AMD) with polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC).
Patients and Methods: Korean case-control group consisting of 112 PCV, 167 CSC patients and 395 control subjects were analyzed. Three single nucleotide polymorphisms (SNPs), ARMS2 rs10490924, HTRA1 rs11200638, and CFH rs1061170, were genotyped in PCV, CSC and control subjects. Differences in the observed genotypic distribution between the case and control groups were analyzed after adjusting for age and sex. Results: ARMS2 rs10490924 and HTRA1 rs11200638 were significantly associated with PCV. There were no SNPs showing significant association with CSC. The genotype distribution of rs10490924 and rs11200638 also differed significantly between PCV and CSC. The risk allele frequency was higher in PCV patients compared to CSC. Conclusions: Genetic risk factors for AMD showed significant association with PCV but not with CSC in Korean patients. | - |
| dc.description.tableofcontents | TABLE OF CONTENTS
I. Introduction II. Methods 1. Study design and patient subjects 2. Single nucleotide selection and genotype analysis 3. Statistical analysis III. Results IV. Discussion V. References VI. 국문초록 | - |
| dc.format | application/pdf | - |
| dc.format.extent | 320074 bytes | - |
| dc.format.medium | application/pdf | - |
| dc.language.iso | en | - |
| dc.publisher | 서울대학교 대학원 | - |
| dc.subject | Polypoidal choroidal vasculopathy | - |
| dc.subject | Central serous chorioretinopathy | - |
| dc.subject | Age-related macular degeneration | - |
| dc.subject | Genetic risk factor | - |
| dc.subject.ddc | 610 | - |
| dc.title | Association of genetic risk factors for age-related macular degeneration with polypoidal choroidal vasculopathy and central serous chorioretinopathy | - |
| dc.title.alternative | 결절 맥락막 혈관병증 및 중심성 장액맥락망막병증 환자에서 연령관련 황반변성의 관련 유전 위험인자의 분석 | - |
| dc.type | Thesis | - |
| dc.contributor.AlternativeAuthor | Ryoo, Na-Kyung | - |
| dc.description.degree | Master | - |
| dc.citation.pages | iv, 21 | - |
| dc.contributor.affiliation | 의과대학 의학과 | - |
| dc.date.awarded | 2014-02 | - |
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