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Sublethal copper deficiency during developmental periods induces cerebral aneurysms : 발생 시기 구리결핍식이를 통한 뇌동맥류의 발생 유도
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이상건 | - |
dc.contributor.author | 신용원 | - |
dc.date.accessioned | 2017-07-19T10:27:32Z | - |
dc.date.available | 2017-07-19T10:27:32Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.other | 000000025147 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132732 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2015. 2. 이상건. | - |
dc.description.abstract | background: Noninvasive pharmacological therapy options are extremely necessary for cerebral aneurysms. To identify the pathophysiological target, we developed an optimal model to review human intracranial aneurysms (IAs).
Methods: Rats were fed copper-free, low-copper, normal, or copper-rich diets at different time periods from gestation to adulthood. The incidences of IAs were evaluated and autopsies were performed to determine the coexistence of cardiovascular diseases. Results: While rats fed a copper-free diet from gestation were associated with high mortality rates (~80%) resulting from ascending aorta aneurysm rupture, a low-copper diet model led to acceptable mortality rates (~18%) and produced IAs and subarachnoid hemorrhage in about 45% and 9%, respectively. Delayed copper supplementation in the rats primed for copper deficiency from gestation failed to decrease the development of aneurysms. Higher proportion of IAs up to 90% in the rats fed with low-copper diet from gestation period can be easily achieved by flow-augmentation by common carotid artery occlusion and/or hypertension induction with deoxycorticosterone acetate. In addition, we proposed genes involving extracellular matrix and vascular remodeling and some miRNAs as effectors of aneurysm development using this model. Conclusion: We propose a simple and relevant model of the human IAs by a simple measure to decrease the activity of lysyl oxidases by dietary copper deficiency from gestation. A highly efficacious method to create IAs without any direct manipulation of intracranial arteries would be a powerful tool for future aneurysm studies. | - |
dc.description.tableofcontents | Abstract..................................................................................................................................i
Contents...............................................................................................................................iii List of tables......................................................................................................................iv List of figures.....................................................................................................................v Introduction..........................................................................................................................1 Material and Methods......................................................................................................2 Results...................................................................................................................................7 Discussion...........................................................................................................................10 References...........................................................................................................................15 Abstract in Korean..........................................................................................................36 | - |
dc.format | application/pdf | - |
dc.format.extent | 804920 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Animal model | - |
dc.subject | Copper | - |
dc.subject | Intracranial aneurysm | - |
dc.subject | Aortic aneurysm | - |
dc.subject | Gestation | - |
dc.subject.ddc | 610 | - |
dc.title | Sublethal copper deficiency during developmental periods induces cerebral aneurysms | - |
dc.title.alternative | 발생 시기 구리결핍식이를 통한 뇌동맥류의 발생 유도 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | v, 36 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2015-02 | - |
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