S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) Theses (Master's Degree_의학과)
Interstitial Pneumonia Pattern on Day 7 Chest radiograph Predicts Bronchopulmonary Dysplasia in Preterm Infants
미숙아에서 생후 7일째 흉부 방사선 사진에서 보이는 간질성 폐렴 양상이 기관지폐이형성증의 발생을 예측한다
- 의과대학 의학과
- Issue Date
- 서울대학교 대학원
- Bronchopulmonary dysplasia; Interstitial pneumonia pattern; very low birth weight infant; Chest radiograph
- 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2017. 2. 최창원.
- Introduction: Early identification of infants at higher risk of developing bronchopulmonary dysplasia (BPD) may allow a targeted approach for reducing BPD. We aimed to evaluate the hypothesis that interstitial pneumonia pattern on day 7 chest radiograph predicts BPD or death before 36 weeks postmentrual age(PMA).
Methods: We retrospectively reviewed the medical charts of 336 preterm infants whose birth weights were <1,500 g and gestational ages were <32 postmenstrual weeks. Data were collected from 304 preterm infants admitted to Seoul National University Bundang Hospital between January 2008 and December 2014. Day 7 chest radiographs were independently reviewed by two pediatric radiologists who were unaware of the clinical information on the individual infant.
Results: Interstitial pneumonia pattern on day 7 chest radiograph was independently associated with BPD or death before 36 weeks PMA (odds ratio [OR] 4.03, 95% confidence interval [CI] 1.13-14.43). Interstitial pneumonia pattern on day 7 chest radiograph predicted BPD or death with 25.0% sensitivity, 97.79% specificity, 88.57% positive predictive value, and 65.79% negative predictive value. Histologic chorioamnionitis was a preceding factor that was independently associated with interstitial pneumonia pattern on day 7 chest radiograph (OR 3.73, 95% CI 1.34-10.33).
Conclusions: Interstitial pneumonia pattern on day 7 chest radiograph has a high specificity for predicting BPD or death and can be utilized to select high risk preterm infants who will benefit most from preventive intervention against BPD.