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Atorvastatin promotes adult epicardial progenitors differentiation into endothelial cells under the myocardial infarction condition through KLF2
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김효수 | - |
dc.contributor.author | 양혜림 | - |
dc.date.accessioned | 2017-07-19T10:39:15Z | - |
dc.date.available | 2017-07-19T10:39:15Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.other | 000000009674 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132973 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의과학과 의과학 전공, 2013. 2. 김효수. | - |
dc.description.abstract | Myocardial infarction(MI) is related to inflammatory response, leading to the fibrosis that occurs in response to injured stimuli inducing cardiomyocyte death. Epicardial progenitor cells (EpiPCs) have been identified from adult epicardium as well as during development and may be differentiated for renewal of vessels at low basal level or neovascularization following cardiac injury.
Here, we discovered that atorvastatin promotes KLF2 activation via ERK5, which induces the differentiation of adult epicardial cells into endothelial cells (ECs) and also promotes vessel formation, not fibroblast causing fibrosis, which suppressed fibroblast factor such as Snail. | - |
dc.description.tableofcontents | CONTENTS i
List of Figures iii List of Tables iv ABSTRACT v INTRODUCTION 1 METHODS 4 RESULTS 8 DISCUSSION 15 CONCLUSION 18 REFERENCES 19 FIGURES 23 TABLES 39 국문초록 41 | - |
dc.format | application/pdf | - |
dc.format.extent | 3210174 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 610 | - |
dc.title | Atorvastatin promotes adult epicardial progenitors differentiation into endothelial cells under the myocardial infarction condition through KLF2 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Yang Hye-Rim | - |
dc.description.degree | Master | - |
dc.citation.pages | 50 | - |
dc.contributor.affiliation | 의과대학 의과학과 | - |
dc.date.awarded | 2013-02 | - |
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