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비만관련 유전자의 유전적 변이와 유방암 위험도 간의 연관성 연구
Genetic variation in obesity-related genes and risk for breast cancer

DC Field Value Language
dc.contributor.advisor최지엽-
dc.contributor.author정서강-
dc.date.accessioned2017-07-19T10:40:15Z-
dc.date.available2017-07-19T10:40:15Z-
dc.date.issued2014-02-
dc.identifier.other000000018777-
dc.identifier.urihttp://hdl.handle.net/10371/132993-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2014. 2. 최지엽.-
dc.description.abstractWe clarified that the associations of previous known obesity-related genes including RBFOX1 with BMI and novel intergenic region which may linked to obesity was confirmed. Also, the BMI-related genes were significantly associated with breast cancer risk in pathway analysis and the association was different by menopausal status and BMI levels, although the association was need for identification through additional validation study.-
dc.description.tableofcontentsContents

Introduction 1

1. Increased prevalence of obesity 3
2. Established risk factors for breast cancer development 8
3. Association between obesity and risk of breast cancer 10
4. Previous association studies on obesity related genetic factors and breast cancer risk 14

Objectives 17

Materials and methods 18

1. Study population 18
2. Genotyping and quality control of DNA 22
3. Gene and SNP selection for obesity and genotyping 25
4. Statistical analyses 30

Results 37

1. Characteristics of participants 37
2. Findings of obesity-related SNP and genes with BMI 41
3. Findings of individual genetic variants with BMI on breast cancer risk 46
4. Findings of gene-based pathway analysis related to BMI on breast cancer risk 48

Discussion 55

Reference 61

Abstract in Korean 71
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dc.formatapplication/pdf-
dc.format.extent1603698 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectBreast cancer-
dc.subjectobesity-related genes-
dc.subjectpathway analysis-
dc.subjectpolymorphism-
dc.subject.ddc610-
dc.title비만관련 유전자의 유전적 변이와 유방암 위험도 간의 연관성 연구-
dc.title.alternativeGenetic variation in obesity-related genes and risk for breast cancer-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pages73-
dc.contributor.affiliation의과대학 의과학과-
dc.date.awarded2014-02-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Theses (Master's Degree_의과학과)
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