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비만관련 유전자의 유전적 변이와 유방암 위험도 간의 연관성 연구 : Genetic variation in obesity-related genes and risk for breast cancer
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 최지엽 | - |
| dc.contributor.author | 정서강 | - |
| dc.date.accessioned | 2017-07-19T10:40:15Z | - |
| dc.date.available | 2017-07-19T10:40:15Z | - |
| dc.date.issued | 2014-02 | - |
| dc.identifier.other | 000000018777 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/132993 | - |
| dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2014. 2. 최지엽. | - |
| dc.description.abstract | We clarified that the associations of previous known obesity-related genes including RBFOX1 with BMI and novel intergenic region which may linked to obesity was confirmed. Also, the BMI-related genes were significantly associated with breast cancer risk in pathway analysis and the association was different by menopausal status and BMI levels, although the association was need for identification through additional validation study. | - |
| dc.description.tableofcontents | Contents
Introduction 1 1. Increased prevalence of obesity 3 2. Established risk factors for breast cancer development 8 3. Association between obesity and risk of breast cancer 10 4. Previous association studies on obesity related genetic factors and breast cancer risk 14 Objectives 17 Materials and methods 18 1. Study population 18 2. Genotyping and quality control of DNA 22 3. Gene and SNP selection for obesity and genotyping 25 4. Statistical analyses 30 Results 37 1. Characteristics of participants 37 2. Findings of obesity-related SNP and genes with BMI 41 3. Findings of individual genetic variants with BMI on breast cancer risk 46 4. Findings of gene-based pathway analysis related to BMI on breast cancer risk 48 Discussion 55 Reference 61 Abstract in Korean 71 | - |
| dc.format | application/pdf | - |
| dc.format.extent | 1603698 bytes | - |
| dc.format.medium | application/pdf | - |
| dc.language.iso | en | - |
| dc.publisher | 서울대학교 대학원 | - |
| dc.subject | Breast cancer | - |
| dc.subject | obesity-related genes | - |
| dc.subject | pathway analysis | - |
| dc.subject | polymorphism | - |
| dc.subject.ddc | 610 | - |
| dc.title | 비만관련 유전자의 유전적 변이와 유방암 위험도 간의 연관성 연구 | - |
| dc.title.alternative | Genetic variation in obesity-related genes and risk for breast cancer | - |
| dc.type | Thesis | - |
| dc.description.degree | Master | - |
| dc.citation.pages | 73 | - |
| dc.contributor.affiliation | 의과대학 의과학과 | - |
| dc.date.awarded | 2014-02 | - |
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