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Development of an optoelectronic neural stimulator using a photovoltaic cell integrated with a light emitting diode for in-vivo optogenetics
생체 광유전학 연구를 위한 발광다이오드와 광전지가 집적된 광전자 신경 자극기의 개발

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dc.contributor.advisor송윤규-
dc.contributor.authorNa Ra Choi-
dc.date.accessioned2017-07-19T10:57:58Z-
dc.date.available2017-07-19T10:57:58Z-
dc.date.issued2017-02-
dc.identifier.other000000141139-
dc.identifier.urihttps://hdl.handle.net/10371/133228-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 융합과학부, 2017. 2. 송윤규.-
dc.description.abstractNeural stimulation by light in optogenetics present a new approach to stimulate targeted neuron compared to electrical stimulation that affects another cell. This paper indicates the development of a wireless implantable optoelectronic neural stimulator for optogenetic research using photovoltaic (PV) cells and light emitting diodes (LEDs). The micro LED was used to stimulate the photo-responsible cells and the PV was coupled together to turn on the LED. The GaAs-based PV device is designed near infrared light with high tissue penetration, and it is made of a tandem structure composed of three layers with optimized height to increase the absorption rate of light. Using the standard micro-electronic fabrication process, the PV and the LED were made and bonded. The stimulator was designed in the shape of a micro-sized cube with 400 μm sides. It is small enough to be implanted in the brain and also possible for deep brain stimulation. In this experiment, we demonstrated that PV can generate enough energy to turn on the LED with high efficiency of 34 %. And we show that the emitted light of the stimulator can stimulate the HEK cell using patch clamp set-up. Therefore, the induced photocurrents by our stimulator would be sufficient enough to evoke neuronal firing if our stimulator was implanted in the mammalian brain.-
dc.description.tableofcontentsChapter 1. Introduction 1
1.1. Optogenetic 1
1.2. Motivation 3
1.3. Blue light and near infrared (NIR) light 6
1.4. Optoelectronic neural stimulator 9
Chapter 2. Material and Method 11
2.1. Light emitting diode (LED) and photovoltaic (PV) cell 11
2.1.1. Light emitting diode (LED) 11
2.1.2. Photovoltaic (PV) cell 14
2.2. Concavo-convex structure design 16
2.3. Fabrication process 18
2.4. Integration PV and LED 21
2.5. Light source and measurement 24
2.6. HEK cell culture and transfection for in-vitro electrophysiology experiment 25
Chapter 3. Result and Discussion 28
3.1. Concavo-convex structure 28
3.2. The characterization of LED and PV 30
3.3. Structural result of integrated device 33
3.4. Optoelectronic neural stimulator 36
3.5. In-vitro experiment 39
Chapter 4. Conclusion 41
References 42
요약 (국문초록) 47
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dc.formatapplication/pdf-
dc.format.extent2233258 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectOptogenetic-
dc.subjectOptoelectronic-
dc.subjectNeural Stimulator-
dc.subjectPhotovoltaic cell-
dc.subjectlight emitting diode-
dc.subject.ddc620-
dc.titleDevelopment of an optoelectronic neural stimulator using a photovoltaic cell integrated with a light emitting diode for in-vivo optogenetics-
dc.title.alternative생체 광유전학 연구를 위한 발광다이오드와 광전지가 집적된 광전자 신경 자극기의 개발-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pagesxii, 48-
dc.contributor.affiliation융합과학기술대학원 융합과학부-
dc.date.awarded2017-02-
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Transdisciplinary Studies(융합과학부)Theses (Master's Degree_융합과학부)
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