Molecular Mechanisms of Dicentra Formosa Analgesic effect

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Royale Jarreau Gray-Lee
Uhtaek, Oh
융합과학기술대학원 분자의학 및 바이오제약학과
Issue Date
서울대학교 융합과학기술대학원
Master’s Thesis
학위논문 (석사)-- 서울대학교 융합과학기술대학원 : 바이오제약학과, 2016. 8. 오우택.
Surgeons, Native Americans and Eclectics have all sworn to the multiple healing properties including anthelmintic, analgesic, and anti-cancer effects that Dicentra Formosa possess. However, none of the above provided any scientifically proven data to conclude the healing properties of Dicentra Formosa as fact. Here, Ive examined the analgesic effect of Dicentra Formosa in two pain models and also identified the molecular target for the analgesic effect of Dicentra.

In the chronic pain model of carrageenan-induced inflammation and sciatic nerve ligation, I observed that the threshold for thermal and mechanical nociception was increased in Dicentra-treated mice compared to the vehicle-treated group. As TRP channels, especially TRPV1 and TRPA1 are known to play a crucial role in the hypersensitivity to thermal and mechanical stimuli, we proceeded to test the analgesic effect of Dicentra Formosa on TRPV1, TRPA1 channel activities. Calcium imaging and Patch Clamp recordings revealed Dicentra Formosa to have an antagonistic effect on the TRPA1 channel comparable to the known TRPA1 antagonist, HC-030031. However, Dicentra Formosa showed no inhibitory effect on the TRPV1 channel.

Therefore Dicentra Formosa shows a substantial analgesic effect in inflamed and neuropathic pain, which is presumably mediated by the inhibition of TRPA1 channel. These findings are the first scientific report for analgesic effect of Dicentra Formosa, which provides potential therapeutic promise of Dicentra Formosa for pain relief.
Key words: Dicentra Formosa, Analgesic, Pain, Thermal / Mechanical nociception, TRPA1, TRPV1
Student Number: 2014-24852
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Theses (Master's Degree_분자의학 및 바이오제약학과)
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