S-Space College of Pharmacy (약학대학) Dept. of Manufacturing Pharmacy (제약학과) Theses (Master's Degree_제약학과)
Gombamide A, a Cyclic Thiopeptide from the Sponge Clathria gombawuiensis : Clathria gombawuiensis 한국해면에서 분리한 신규 Peptide
- 약학대학 제약학과
- Issue Date
- 서울대학교 대학원
- Clathria gombawuiensis ; a Cyclic C-terminally-modified Thiohexapeptide ; the Unusual Amino Acid Residues
- 학위논문 (석사)-- 서울대학교 대학원 : 제약학과, 2014. 2. 신종헌.
- A new peptide, gombamide A (1), was isolated from the marine sponge Clathria gombawuiensis, collected from Korean waters. Based on the results of combined spectroscopic analyses, the structure of this compound was determined to be a cyclic C-terminally-modified thiohexapeptide containing the unusual amino acid residues para-hydroxystyrylamide (pHSA) and pyroglutamicacid (pyroGlu). The absolute configurations of all amino acid residues were determined to be L by advanced Marfeys analysis. The new compound exhibited weak cytotoxicity against A549 and K562 cell lines as well as moderate inhibitory activity against Na+/K+-ATPase.