Browse

Separacenes A–C, Cytotoxic Polyene Polyketides from the Marine Actinomycete, Streptomyces sp.

DC Field Value Language
dc.contributor.advisor오 동 찬-
dc.contributor.author배문형-
dc.date.accessioned2017-07-19T11:12:40Z-
dc.date.available2017-07-19T11:12:40Z-
dc.date.issued2013-02-
dc.identifier.other000000009203-
dc.identifier.urihttps://hdl.handle.net/10371/133453-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2013. 2. 오동찬.-
dc.description.abstractDuring our search for new secondary metabolites with pharmaceutical potential, marine actinomycete strains, collected from Shinyang Beach in Jeju Island, were chemically analyzed by LC/MS. One of the marine actinomycetes strains, SNW10 (Streptomyces sp. based on 16S rDNA analysis), was revealed to produce unique tetraene / triene-bearing metabolites, which named separacenes A-C. The structures of the separacenes were determined by spectroscopic analysis of 1D and 2D NMR, MS and UV data. Separacene A possessing terminal olefinic double bond, conjugated tetraene, and two 1,2-diol groups, turned out to be a new 15-membered linear polyketide. The absolute configuration of separacene A was established by modified Moshers method. The structures of separacene B and C, which incorporate terminal olefinic methylene, tirene, and two 1,2-diol moieties, were also elucidated by spectroscopic analysis and chemical derivatization. Separacene A displayed cytotoxic activity against the HCT116 and A549 cancer cell line.-
dc.description.tableofcontentsSignature page i
Abstract ii
List of Contets iv
List of Tables v
List of Figures vi
Introduction 1
Results and discussion 3
Experimental section 14
References 37
Abstract in Korean 38
-
dc.formatapplication/pdf-
dc.format.extent1444040 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectlinear polyketides-
dc.subjectseparacene-
dc.subjectmarine actinomycete.-
dc.subject.ddc615-
dc.titleSeparacenes A–C, Cytotoxic Polyene Polyketides from the Marine Actinomycete, Streptomyces sp.-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pages38-
dc.contributor.affiliation약학대학 약학과-
dc.date.awarded2013-02-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Master's Degree_약학과)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse