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Stereoselective Synthesis of D-5-Homo-4-selenonucleosides as Potent Therapeutic Agents
효과적인 치료제로서의 D-5-Homo-4-selenonucleosides의 입체 선택적 합성

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Authors
최유진
Advisor
정낙신
Major
약학대학 약학과
Issue Date
2016-02
Publisher
서울대학교 대학원
Keywords
D-5’-Homo-4’-selenonucleosidesSharpless asymmetric epoxidationRegioselective cleavageStereoselective reduction
Description
학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과 약품화학전공, 2016. 2. 정낙신.
Abstract
D-5-Homo-4-selenonucleosides were synthesized from D-5-homo-4-selenoribose using a Pummerer-type condensation. For the stereoselective synthesis of the key intermediate D-5-homo-4-selenoribose, we employed Sharpless asymmetric epoxidation, regioselective epoxide cleavage, and stereoselective reduction of the ketone as the key steps.
Language
English
URI
https://hdl.handle.net/10371/133627
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Master's Degree_약학과)
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