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Structure elucidation of new polyketide-derived secondary metabolites from bacteria in extreme habitats
극한 환경에서 서식하는 미생물로부터 분리한 polyketide에서 유래된 새로운 이차대사물질의 구조 규명

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Authors
김정우
Advisor
오동찬
Major
약학대학 약학과
Issue Date
2017-02
Publisher
서울대학교 대학원
Keywords
Secondary metabolitessalternAlaskan permafrostactinomycete
Description
학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과, 2017. 2. 오동찬.
Abstract
Bacteria inhabiting extreme environments have been considered as attracting resources for bioactive compounds. As part of continuing efforts to explore the chemical diversity of bacteria from extreme habitats for drug discovery, in this study, bacterial strains inhabiting saltern and Alaskan permafrost have been investigated. Actinobacterial strains were isolated from these extreme habitats, cultivated, and chemically analyzed by LC/MS. Based on the bacterial chemical profiles acquired by LC/MS analysis, four new polyketide-derived compounds including three new macrolides and an oxazole-bearing compound were discovered. The structures of the new natural products were elucidated by the analysis of spectroscopic data such as 1D and 2D NMR, mass, UV, and IR spectra.
Language
English
URI
https://hdl.handle.net/10371/133658
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Master's Degree_약학과)
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