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Water Soluble Polymerized Metabolic Precursors Based on PEG-PAMAM-Ac3ManNAz System for Epigenetic Targeting

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Authors
고은호
Advisor
안철희
Major
공과대학 재료공학부
Issue Date
2017-08
Publisher
서울대학교 대학원
Keywords
Tumor HeterogeneityMetabolic GlycoengineeringEpigenetic TargetingCopper-Free Click ChemistryLinear-Dendritic Block CopolymerSelf-Assembly
Description
학위논문 (석사)-- 서울대학교 대학원 공과대학 재료공학부, 2017. 8. 안철희.
Abstract
Over the past several decades, various drug delivery systems have been studied to minimize the side effects of anticancer agents and to increase delivery efficiency to cancer. Despite the development of numerous targeting moiedties, several obstacles remain. Tumor heterogeneity and quantitative limitation of targeted biomolecules are reasons why chemotherapy failed to suppress cancers completely.
In this study, we developed hydrolysable polymerized metabolic precursors (pMPs) by conjugating PEG-PAMAM linear dendritic block copolymers (LDBC) and triacetylated N-azidoacetyl-mannosamine (Ac3ManNAz) via Steglich esterification. As the carboxylic acids of the dendron disappear, pMPs became amphiphilic block copolymers and formed self assembly of 150 nm in aqueous condition. Regardless of genetic phenotypes of tumor cells, pMPs can generate receptor-like azide groups on the cancer cell surface. Furthermore, the azide groups were visualized by ADIBO-Cy5.5 via copper-free click chemistry in vitro condition. It is expected that pMPs have synergy with the enhanced premeability and retention (EPR) effect and hypersialylation of tumor cells to enable tumor cell specific glycan labeling in vivo condition.
Language
English
URI
https://hdl.handle.net/10371/137396
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Material Science and Engineering (재료공학부) Theses (Master's Degree_재료공학부)
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