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Natural history of intraductal papillary mucinous neoplasm of pancreas during surveillance: focusing on cyst growth and manifestation of worrisome features : 췌관내유두상점액종의 장기 추적관찰을 통한 자연경과의 고찰
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김호 | - |
dc.contributor.author | 한영민 | - |
dc.date.accessioned | 2017-10-31T08:00:13Z | - |
dc.date.available | 2017-10-31T08:00:13Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.other | 000000145481 | - |
dc.identifier.uri | https://hdl.handle.net/10371/137684 | - |
dc.description | 학위논문 (석사)-- 서울대학교 보건대학원 보건학과, 2017. 8. 김호. | - |
dc.description.abstract | Background: To evaluate the natural history of branch-duct intraductal papillary mucinous neoplasms (BD-IPMN) of the pancreas under surveillance and to recommend optimal follow up intervals and duration.
Methods: We included only patients whose imaging studies showed classical features of BD-IPMN, and conducted follow-up periods of at least 3 years. We reviewed radiologic and pathologic findings, and performed linear and binary logistic regressions to estimate cyst growth. Results: We identified 1,369 patients diagnosed with BD-IPMN. The median annual growth rate of the cyst was 0.6 mm over a median follow-up time of 61 months. During surveillance, 46 patients (3.4%) underwent surgery due to disease progression after a median follow-up time (in this group) of 62 months. Worrisome features were observed in 171 patients (12.5%) during surveillance, including cyst size >3 cm (n=47, 3.4%), cyst wall thickening (n=51, 3.7%), main pancreatic duct (MPD) dilatation (n=78, 5.7%) and mural nodule (n=43, 3.1%). Along with annual cyst growth rate, incidences of MPD dilatation, cyst wall thickening and mural nodules were related to initial sizes of cysts at detection (P<0.001). Conclusion: Most BD-IPMN appear indolent, but some exhibit rapid growth and progression. Therefore, surveillance protocols should be individualized with regards to the natural history of BD-IPMNs focusing on initial cyst size and growth rate. | - |
dc.description.tableofcontents | 1. Introduction --------------------------- 1
2. Materials & Methods ------------------ 2 3. Results --------------------------- 6 4. Discussion --------------------------- 15 5. References --------------------------- 22 | - |
dc.format | application/pdf | - |
dc.format.extent | 384140 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 보건대학원 | - |
dc.subject | Intraductal papillary mucinous neoplasm of pancreas | - |
dc.subject | IPMN | - |
dc.subject | Natural history | - |
dc.subject.ddc | 614 | - |
dc.title | Natural history of intraductal papillary mucinous neoplasm of pancreas during surveillance: focusing on cyst growth and manifestation of worrisome features | - |
dc.title.alternative | 췌관내유두상점액종의 장기 추적관찰을 통한 자연경과의 고찰 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Youngmin Han | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 보건대학원 보건학과 | - |
dc.date.awarded | 2017-08 | - |
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