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Good correlation of HPV DNA test between self-collected vaginal and clinician-collected cervical samples by the oligonucleotide microarray
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Sang-Soo | - |
dc.contributor.author | Song, Yong-Sang | - |
dc.contributor.author | Kim, Jae-Weon | - |
dc.contributor.author | Park, Noh-Hyun | - |
dc.contributor.author | Kang, Soon-Beom | - |
dc.contributor.author | Lee, Hyo-Pyo | - |
dc.date.accessioned | 2009-11-23T05:29:19Z | - |
dc.date.available | 2009-11-23T05:29:19Z | - |
dc.date.issued | 2005-12-27 | - |
dc.identifier.citation | Gynecol Oncol. 2006 Jul;102(1):67-73. Epub 2006 Jan 10. | en |
dc.identifier.issn | 0090-8258 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16375952 | - |
dc.identifier.uri | https://hdl.handle.net/10371/13770 | - |
dc.description.abstract | OBJECTIVES: To evaluate the efficacy of self-collected vaginal samples for high-risk HPV detection by the HPV oligonucleotide microarray method (HPVDNAChip). METHODS: One hundred and eighteen patients with abnormal Pap smears were included. Self-collected vaginal and clinician-collected cervical samples for HPV testing were obtained. The result of the HPV DNA test was compared with the histopathological diagnosis or colposcopic finding. RESULTS: Of the 118 patients, 42 (35.6%) had >or= cervical intraepithelial neoplasia (CIN) III lesions. Using the HPVDNAChip, high-risk types of HPV were detected in 38 of these 42 patients (90.5%) with the self-collected vaginal samples and in 37 of 42 (88.1%) with the clinician-collected cervical samples. The agreement of HPVDNAchip results between self- and clinician-collected samples was very good (kappa = 0.81) with a 93.2% concordance rate. Multiple HPV infections were found in 17 of 88 (19.3%) HPV-positive clinician-collected cervical samples. The rate of multiple HPV infection tended to decrease as the degree of pathologic classification increased. CONCLUSION: Using the HPVDNAchip to assay for HPV infection, results from self-collected vaginal samples were compatible with those from clinician-collected cervical samples. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Cervix Uteri/cytology/*virology | en |
dc.subject | DNA, Viral/*genetics | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Middle Aged | en |
dc.subject | Oligonucleotide Array Sequence Analysis/methods | en |
dc.subject | Risk Factors | en |
dc.subject | Self Care/methods | en |
dc.subject | Uterine Cervical Neoplasms/pathology/*virology | en |
dc.subject | Vaginal Smears/*methods | en |
dc.title | Good correlation of HPV DNA test between self-collected vaginal and clinician-collected cervical samples by the oligonucleotide microarray | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 서상수 | - |
dc.contributor.AlternativeAuthor | 송용상 | - |
dc.contributor.AlternativeAuthor | 김재원 | - |
dc.contributor.AlternativeAuthor | 박노현 | - |
dc.contributor.AlternativeAuthor | 강순범 | - |
dc.contributor.AlternativeAuthor | 이효표 | - |
dc.identifier.doi | 10.1016/j.ygyno.2005.11.030 | - |
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