S-Space College of Education (사범대학) Dept. of Science Education (과학교육과) Chemistry (화학전공) Theses (Master's Degree_화학전공)
Stability of silica-based nanoparticles
실리카계 나노 입자의 안정성에 대한 연구
- Junhua Yu
- 사범대학 과학교육과
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 사범대학 과학교육과, 2017. 8. Junhua Yu.
- Silica has received huge attention and is broadly applied to biomedical application due to advantageous properties such as low toxicity, biocompatibility and tunable synthesis in particle size, porosity and shape render. Though stable in water and phosphate buffered saline, silica nanoparticles are eroded by biological media, leading to the exposure of AgNDs from AgND@SiO2 nanoparticles and the quenching of nanodot luminescence. It have presented that a synergistic effect of organic components in cellular media, particularly the amino groups, accelerates the erosion. The results indicate that silica nanostructures are vulnerable to cellular medium and the tendency may depend on porosity and presence of foreign substance in silica layer. This study may be possible to tune the release of drug molecules from silica-based drug delivery vehicles through controlled erosion.