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Enhanced drug delivery systems using pH-responsive peptides and reverse electrodialysis : pH-응답성 펩타이드와 역전기투석을 이용한 향상된 약물 전달 시스템
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이연 | - |
dc.contributor.author | 장주명 | - |
dc.date.accessioned | 2017-10-31T08:34:44Z | - |
dc.date.available | 2020-10-06T08:47:58Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.other | 000000145760 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138105 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 자연과학대학 화학부, 2017. 8. 이연. | - |
dc.description.abstract | The purpose of this study was to increase the efficacy and safety of drugs in the biosystem. Two methods have been used in my research.
First study is giving pH-selectivity to LK peptide which is a cell penetrating peptide composed of leucine (L) and lysine (K) with high cell penetrating ability at 10 nM level. I introduced histidine (H) with a pKa of 6.0 in the sequence of the LK peptide to introduce pH-sensitivity into the peptide. As a result, I have developed a new LH peptide which can be protonated at about pH 6 and represent positive charges for the internalization into cells. The LH peptide could be used as an cancer-targeting drug carrier, because the pH around cancerous tissues is about 5-6. I confirmed that the LH peptide selectively penetrates into the cells depending on the pH. Moreover, I compared the toxicity of the LH peptide at different pH conditions. Secondly, I introduced Reverse Electrodialysis (RED) into transdermal drug delivery system. RED patch could generate the electrical energy from the ion gradient of two salt solution of different concentrations across ion-selective membranes. I used the generated electrical energy for delivering ionic drugs into skin. I confirmed that the ionic drugs were efficiently delivered by the RED system in in vitro penetration test. Finally, through a cooperative research, I examined the in vivo pharmacological effects of risedronate delivered by RED in osteoporosis-induced mouse models. I believed that both studies will be used as effective alternatives for drug delivery with high efficiency and safety in near future. | - |
dc.description.tableofcontents | Part Ⅰ 1
1. Introduction 1 2. Materials and Methods 4 3. Results 9 4. Discussion 11 5. Summary 13 Part Ⅱ 14 1. Introduction 14 2. Materials and Methods 16 3. Results 22 4. Discussion 26 5. Summary 30 Conclusion 31 References 32 Figures 35 국문 초록 (Abstract in Korean) 54 | - |
dc.format | application/pdf | - |
dc.format.extent | 940727 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | pH-selectivity | - |
dc.subject | Cell penetrating peptide | - |
dc.subject | Reverse electrodialysis(RED) | - |
dc.subject | Transdermal drug delivery | - |
dc.subject | Iontophoresis | - |
dc.subject | Osteoporosis | - |
dc.subject | Risedronate | - |
dc.subject.ddc | 540 | - |
dc.title | Enhanced drug delivery systems using pH-responsive peptides and reverse electrodialysis | - |
dc.title.alternative | pH-응답성 펩타이드와 역전기투석을 이용한 향상된 약물 전달 시스템 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 자연과학대학 화학부 | - |
dc.date.awarded | 2017-08 | - |
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