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Occupations and Parkinson's disease: a multi-center case-control study in South Korea

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dc.contributor.authorPark, Jungsun-
dc.contributor.authorYoo, Cheol-In-
dc.contributor.authorSim, Chang Sun-
dc.contributor.authorKim, Hyo Kyung-
dc.contributor.authorKim, Jae Woo-
dc.contributor.authorJeon, Beom S-
dc.contributor.authorKim, Ki-Rak-
dc.contributor.authorBang, Oh-Young-
dc.contributor.authorLee, Won-Yong-
dc.contributor.authorYi, Yunjeong-
dc.contributor.authorJung, Kap-Yeol-
dc.contributor.authorChung, Soo-Eun-
dc.contributor.authorKim, Yangho-
dc.date.accessioned2009-11-23T06:09:15Z-
dc.date.available2009-11-23T06:09:15Z-
dc.date.issued2004-11-06-
dc.identifier.citationNeurotoxicology. 2005 Jan;26(1):99-105.en
dc.identifier.issn0161-813X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15527877-
dc.identifier.urihttp://hdl.handle.net/10371/13824-
dc.description.abstractOBJECTIVE: We performed a hospital based case-control study in South Korea (1) to clarify the role of occupational exposure, and especially manganese (Mn) exposure in the etiology of Parkinson's disease (PD) and (2) to discover the association between any occupations and PD. METHODS: We selected two groups, PD patient group (N1) and controls (N2). Three hundred sixty-seven consecutive outpatients with PD (177 men, 190 women) and 309 controls were interviewed about life style, past history, family history, education level, and occupational history etc. We employed a range of industrial categories as defined by section (the most broad category) and division (sub-category) of the Korea Standard Industry Code (KSIC) Manual. Along with KSIC, we also used the Korea Standard Classification of Occupations (KSCO) as proxies of occupational exposure. The odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for age, sex, smoking status, and education level are presented. RESULTS: As regarding the exposure to hazardous materials, especially Mn, more subjects in the control group than the PD patient group have worked in the occupations with potential exposure to Mn (P < 0.001). Ever having worked in 'agriculture, hunting, and forestry' section of industry was positively associated with PD (OR 1.88), and 'agriculture production crops (OR 1.96)' division of industry was positively associated with PD. On the other hand, ever having worked in the 'manufacturing (OR 0.56)', 'transportation (OR 0.28)' section of industry, and 'transporting (OR 0.20)' division of industry were negatively associated with PD. 'Drivers (OR 0.13)' division of occupation also was negatively associated with PD. CONCLUSIONS: To our knowledge, this is the first case-control studies to find an inverse relationship between 'transporting' or 'technicians like machinery engineers' as his/her longest job and PD risk. Because of this unexpected finding, our work should be replicated in various populations.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAge of Onseten
dc.subjectAgeden
dc.subjectCase-Control Studiesen
dc.subjectEducationen
dc.subjectFemaleen
dc.subjectHazardous Substancesen
dc.subjectHumansen
dc.subjectIndustryen
dc.subjectKorea/epidemiologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOccupational Exposure/adverse effectsen
dc.subjectOccupations/*statistics & numerical dataen
dc.subjectParkinson Disease/*epidemiologyen
dc.subjectQuestionnairesen
dc.subjectRisk Factorsen
dc.subjectSex Factorsen
dc.subjectSmoking/epidemiologyen
dc.subjectWater Supplyen
dc.titleOccupations and Parkinson's disease: a multi-center case-control study in South Koreaen
dc.typeArticleen
dc.contributor.AlternativeAuthor박정선-
dc.contributor.AlternativeAuthor유철인-
dc.contributor.AlternativeAuthor심창선-
dc.contributor.AlternativeAuthor김효경-
dc.contributor.AlternativeAuthor김재우-
dc.contributor.AlternativeAuthor방오영-
dc.contributor.AlternativeAuthor이원용-
dc.contributor.AlternativeAuthor이윤정-
dc.contributor.AlternativeAuthor정갑열-
dc.contributor.AlternativeAuthor정수은-
dc.contributor.AlternativeAuthor김양호-
dc.identifier.doi10.1016/j.neuro.2004.07.001-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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