Publications
Detailed Information
Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Seorin | - |
dc.contributor.author | Lee, Kyoungbun | - |
dc.contributor.author | Wen, Xianyu | - |
dc.contributor.author | Kim, Younghoon | - |
dc.contributor.author | Cho, Nam-Yun | - |
dc.contributor.author | Jang, Ja-June | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.date.accessioned | 2017-11-02T00:50:16Z | - |
dc.date.available | 2017-11-02T09:56:25Z | - |
dc.date.issued | 2017-08-29 | - |
dc.identifier.citation | BMC Cancer, 17(1):588 | ko_KR |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138280 | - |
dc.description | ECC: Extrahepatic cholangiocarcinoma; ICC: Intrahepatic cholangiocarcinoma;
IG: Intraductal growth; LINE-1: Long interspersed element-1; MF: Mass-forming; PI: Periductal infiltrative; TNM: Tumor, node, and metastasis | ko_KR |
dc.description.abstract | Abstract
Background DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5′ untranslated region methylated heavily in normal cells and undergoes demethylation in association with cancerization. However, little information is available regarding LINE-1 hypomethylation and its prognostic implication in intrahepatic cholangiocarcinomas. Methods A total of 172 cases of intrahepatic cholangiocarcinomas were analyzed for their methylation levels at four CpG sites of LINE-1 using bisulfite pyrosequencing. We examined the relation between tumoral LINE-1 methylation level and clinicopathological features, including survival. Results Tumor differentiation, lymphatic invasion, and T stage were associated with a low average methylation level of LINE-1 at the four CpG sites; LINE-1 methylation level tended to be lower in high-grade differentiation, lymphatic emboli, and higher T stage. LINE-1 hypomethylation was significantly linked with lower cancer-specific survival in patients with intrahepatic cholangiocarcinoma and was found to be an independent prognostic parameter. Conclusions Our findings suggest that tumoral LINE-1 hypomethylation could be a molecular biomarker heralding poor prognosis of patients with intrahepatic cholangiocarcinoma. Our findings need to be validated in further study. | ko_KR |
dc.description.sponsorship | This work was supported by a grant from the National Research Foundation (NRF) grants funded by the Korean Ministry of Science, ICT and Future Planning (2011–0030049 and 2016M3A9B6026921), a grant from the Priority Research Centers Program through the NRF (2009–0093820), and a grant from the Korea Health Technology R & D Project through the Korea Health Industry Development Institute funded by the Korean Ministry of Health and Welfare (HI14C1277). The funding bodies had no role in the design of the study, the collection, analysis, and interpretation of the data, or in the writing of the manuscript. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Cholangiocarcinoma | ko_KR |
dc.subject | Line-1 | ko_KR |
dc.subject | Methylation | ko_KR |
dc.subject | Prognosis | ko_KR |
dc.subject | Pyrosequencing | ko_KR |
dc.title | Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정서린 | - |
dc.contributor.AlternativeAuthor | 이경분 | - |
dc.contributor.AlternativeAuthor | 김영훈 | - |
dc.contributor.AlternativeAuthor | 조남윤 | - |
dc.contributor.AlternativeAuthor | 장자준 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.identifier.doi | 10.1186/s12885-017-3595-8 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-10-03T16:48:06Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.