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Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children

Cited 15 time in Web of Science Cited 21 time in Scopus
Authors
Lim, Youn-Hee; Bae, Sanghyuk; Kim, Bung-Nyun; Shin, Choong Ho; Lee, Young Ah; Kim, Johanna Inhyang; Hong, Yun-Chul
Issue Date
2017-07-26
Publisher
BioMed Central
Citation
Environmental Health, 16(1):79
Keywords
Bisphenol AChildhood exposureChildren’s environmental healthPrenatal exposureSocial impairment
Description
Abbreviations
ASD: Autism spectrum disorder; BMI: Body mass index; BPA: Bisphenol A; DNMT: DNA methyltransferase; EDC: Environment and Development of Children; K-SCQ: Korean version of the Social Communication Questionnaire; LOD: Lower limit of detection
Abstract
Abstract

Background
Prenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social deficits in offspring. We investigated the association between prenatal and postnatal exposure to BPA and social impairments in a sample of 4-year-old children.

Methods
We recruited second-trimester pregnant women between 2008 and 2011, and measured their creatinine-adjusted prenatal urine BPA levels. In 2014-2015, a subset of 4-year-old children born to these women underwent neurobehavioral assessment and physical examination. We collected urine and blood from the children and assessed social impairments, including deficits in social interaction, social communication, and other behavior patterns using the Korean version of the Social Communication Questionnaire (K-SCQ) (n = 304). We examined social impairments associated with prenatal exposure at mid-term pregnancy and postnatal exposure to BPA at 4 years of age, using linear and piecewise linear regression models.

Results
The relationship between prenatal BPA exposure and social communication was non-linear and statistically significant at or above the flexion point for BPA levels of 3.0 μg/g creatinine in girls (58.4%, 95% confidence interval [CI], 6.5% to 135.8%). Each 2-fold increase in postnatal BPA exposure was significantly associated with an 11.8% (95% CI, 0.6% to 24.3%) increase in impairment in social communication in 4-year old girls, as indicated by the linear regression model.

Conclusion
Prenatal and postnatal BPA exposure is associated with social impairment at 4 years of age, particularly in girls.
ISSN
1476-069X
Language
English
URI
http://hdl.handle.net/10371/138310
DOI
https://doi.org/10.1186/s12940-017-0289-2
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Graduate School of Public Health (보건대학원)Dept. of Environmental Health (환경보건학과)Journal Papers (저널논문_환경보건학과)
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