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Anemia is associated with incidence of dementia: a national health screening study in Korea involving 37,900 persons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Su-Min | - |
dc.contributor.author | Shin, Dong Wook | - |
dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Hyeon, Jung Hyeon | - |
dc.contributor.author | Lee, Jinkook | - |
dc.contributor.author | Kim, SangYun | - |
dc.date.accessioned | 2017-12-12T01:03:12Z | - |
dc.date.available | 2017-12-12T10:05:03Z | - |
dc.date.issued | 2017-12-06 | - |
dc.identifier.citation | Alzheimer's Research & Therapy, 9(1):94 | ko_KR |
dc.identifier.issn | 1758-9193 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138441 | - |
dc.description.abstract | Background
The aim of this study was to investigate whether anemia is associated with dementia incidence in the elderly. Methods Using the Korean National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) database, we identified 66-year-old subjects (n = 37,900) who were free of dementia and stroke. Anemia (hemoglobin < 12g/dl for women and < 13g/dl for men) and the severity of anemia (mild, moderate, or severe) were defined using World Health Organization criteria. The incidence of dementia was identified using International Classification of Diseases, Tenth Revision, dementia diagnosis codes (F00, F01, F02, F03, and G30) with prescription of an antidementia drug. Cox proportional hazards regression models were used to assess HRs for dementia incidence according to anemia. Results After adjusting for sex, baseline cognitive state, body mass index, smoking status, household income, disability, depression, hypertension, diabetes, and dyslipidemia, we found a significant association between anemia and dementia incidence (adjusted HR 1.24; 95% CI 1.02–1.51). The adjusted HRs for incidence of dementia according to the severity of anemia were 1.19 (95% CI 0.98–1.45) for those with mild anemia, 1.47 (95% CI 0.97–2.21) for those with moderate anemia, and 5.72 (95% CI 1.84–17.81) for those with severe anemia, showing a significant p value for trend (p = 0.003). Conclusions Anemia is an independent risk factor for dementia incidence, with a marked increase of risk associated with severe anemia. | ko_KR |
dc.description.sponsorship | This study was supported by an unrestricted grant from Hanmi Pharmaceutical Co., Ltd. (HM-IIT-ESO-026) for an investigator-sponsored study. The funder had no role in the design or conduct of the study. All authors declare that they have no conflict of interest with Hanmi Pharmaceutical Co., Ltd., and the NHIS. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Anemia | ko_KR |
dc.subject | Dementia | ko_KR |
dc.subject | Severity of anemia | ko_KR |
dc.subject | ICD-10 | ko_KR |
dc.title | Anemia is associated with incidence of dementia: a national health screening study in Korea involving 37,900 persons | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정수민 | - |
dc.contributor.AlternativeAuthor | 신동욱 | - |
dc.contributor.AlternativeAuthor | 이지은 | - |
dc.contributor.AlternativeAuthor | 현정현 | - |
dc.contributor.AlternativeAuthor | 이진국 | - |
dc.contributor.AlternativeAuthor | 김상윤 | - |
dc.identifier.doi | 10.1186/s13195-017-0322-2 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-12-10T05:00:46Z | - |
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