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Posterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairment

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dc.contributor.authorPyun, Jung-Min-
dc.contributor.authorPark, Young Ho-
dc.contributor.authorKim, Hang-Rai-
dc.contributor.authorSuh, Jeewon-
dc.contributor.authorKang, Min Ju-
dc.contributor.authorKim, Beom Joon-
dc.contributor.authorYoun, Young Chul-
dc.contributor.authorJang, Jae-Won-
dc.contributor.authorKim, SangYun-
dc.date.accessioned2017-12-18T00:45:15Z-
dc.date.available2017-12-18T09:46:32Z-
dc.date.issued2017-12-16-
dc.identifier.citationAlzheimer's Research & Therapy, 9(1):99ko_KR
dc.identifier.issn1758-9193-
dc.identifier.urihttps://hdl.handle.net/10371/138453-
dc.description.abstractAbstract

Background
In patients with amyloid-positive mild cognitive impairment (MCI), neurodegenerative biomarkers such as medial temporal lobe atrophy (MTA) are useful to predict disease progression to dementia. Although posterior atrophy (PA) is a well-known neurodegenerative biomarker of Alzheimers disease, little is known about PA as a predictor in patients with amyloid-positive MCI.

Methods
We included 258 patients with amyloid-positive MCI with at least one follow-up visit, and who had low cerebrospinal fluid (CSF) β-amyloid1–42 concentration. Data were obtained from the Alzheimers Disease Neuroimaging Initiative study. We assessed PA and MTA on magnetic resonance imaging (MRI) using visual rating scales and retrospectively determined progression to dementia during the follow-up period of up to 3 years (median 24 months). The Cox proportional hazards model was used to analyze hazard ratios (HRs) of PA and MTA for disease progression. Additionally, subjects were divided into four groups according to brain atrophy pattern (no atrophy, MTA only, PA only, both MTA and PA), and HRs for disease progression were compared with the no atrophy reference group. Analyses were conducted with and without adjustment for CSF phosphorylated tau181p (p-tau) and baseline demographics.

Results
A total of 123 patients (47.7%) showed MTA and 174 patients (67.4%) showed PA. Of the total cohort, 139 cases (53.9%) progressed to dementia. PA and MTA were associated with an increased risk for progression to dementia (HR 2.244, 95% confidence interval (CI) 1.497–3.364, and HR 1.682, 95% CI 1.203–2.352, respectively). In the analysis according to atrophy pattern, HR (95% CI) for progression was 2.998 (1.443–6.227) in the MTA only group, 3.126 (1.666–5.864) in the PA only group, and 3.814 (2.045–7.110) in both MTA and PA group. These results remained significant after adjustment.

Conclusions
In patients with amyloid-positive MCI, PA could predict progression to dementia independently of MTA.
ko_KR
dc.description.sponsorshipData collection and sharing for this project was funded by the Alzheimers Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012).ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectPosterior atrophyko_KR
dc.subjectBiomarkersko_KR
dc.subjectDisease progressionko_KR
dc.subjectMild cognitive impairmentko_KR
dc.subjectAlzheimer’s diseaseko_KR
dc.titlePosterior atrophy predicts time to dementia in patients with amyloid-positive mild cognitive impairmentko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor편정민-
dc.contributor.AlternativeAuthor박영호-
dc.contributor.AlternativeAuthor김항래-
dc.contributor.AlternativeAuthor서지원-
dc.contributor.AlternativeAuthor강민주-
dc.contributor.AlternativeAuthor김범준-
dc.contributor.AlternativeAuthor윤영철-
dc.contributor.AlternativeAuthor장재원-
dc.contributor.AlternativeAuthor김상윤-
dc.identifier.doi10.1186/s13195-017-0326-y-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2017-12-17T04:55:30Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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