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Increased epicardial adipose tissue thickness is a predictor of new-onset diabetes mellitus in patients with coronary artery disease treated with high-intensity statins

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dc.contributor.authorKang, Jeehoon-
dc.contributor.authorKim, Young-Chan-
dc.contributor.authorPark, Jin Joo-
dc.contributor.authorKim, Sehun-
dc.contributor.authorKang, Si-Hyuck-
dc.contributor.authorCho, Young Jin-
dc.contributor.authorYoon, Yeonyee E.-
dc.contributor.authorOh, Il-Young-
dc.contributor.authorYoon, Chang-Hwan-
dc.contributor.authorSuh, Jung-Won-
dc.contributor.authorCho, Young-Seok-
dc.contributor.authorYoun, Tae-Jin-
dc.contributor.authorChae, In-Ho-
dc.contributor.authorChoi, Dong-Ju-
dc.date.accessioned2018-01-15T01:01:16Z-
dc.date.available2018-01-15T10:02:09Z-
dc.date.issued2018-01-11-
dc.identifier.citationCardiovascular Diabetology, 17(1):10ko_KR
dc.identifier.issn1475-2840-
dc.identifier.urihttps://hdl.handle.net/10371/138487-
dc.description.abstractBackground
Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicardial adipose tissue (EAT) refers to the visceral fat surrounding the heart, which is associated with metabolic diseases. We sought to determine the association between EAT thickness and NODM in CAD patients treated with high-intensity statins.

Methods
We conducted a retrospective medical record review of CAD patients treated with high-intensity statins for at least 6months after percutaneous coronary intervention performed between January 2009 and June 2013 at Seoul National University Bundang Hospital. EAT thickness was measured by echocardiography using standardized methods.

Results
A total of 321 patients were enrolled, who received high-intensity statins for a mean of 952days; atorvastatin 40mg in 204 patients (63.6%), atorvastatin 80mg in 57 patients (17.8%), and rosuvastatin 20mg in 60 patients (18.7%). During the follow-up period of 3.9±1.7years, NODM occurred in 40 patients (12.5%). On Cox proportional-hazard regression analysis, EAT thickness at systole [for each 1mm: hazard ratio (HR) 1.580; 95% confidence interval (CI) 1.346–1.854; P<0.001] and prediabetes at baseline (HR 4.321; 95% CI 1.998–9.349; P<0.001) were the only independent predictors of NODM. Using binary cutoff values derived from the receiver operating characteristic curve analysis, EAT thickness at systole larger than 5.0mm had an HR of 3.402 (95% CI 1.751–6.611, P<0.001), sensitivity of 52.5%, and specificity of 80.8% for predicting NODM. Also, patients with EAT thickness≥5mm and prediabetes at baseline had a 12.0-times higher risk of developing NODM compared to the risk noted in patients with EAT thickness<5mm and normal glucose tolerance at baseline.

Conclusion
Epicardial adipose tissue thickness at systole is a consistent independent predictor of NODM in patients with CAD treated with high-intensity statins. Such predictors may help physicians plan adequate surveillance for early detection of NODM.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectStatinko_KR
dc.subjectNew-onset diabetes mellitusko_KR
dc.subjectEpicardial adipose tissueko_KR
dc.subjectCoronary artery diseaseko_KR
dc.subjectEchocardiographyko_KR
dc.titleIncreased epicardial adipose tissue thickness is a predictor of new-onset diabetes mellitus in patients with coronary artery disease treated with high-intensity statinsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor강지훈-
dc.contributor.AlternativeAuthor김영찬-
dc.contributor.AlternativeAuthor박진주-
dc.contributor.AlternativeAuthor김세훈-
dc.contributor.AlternativeAuthor강시혁-
dc.contributor.AlternativeAuthor조영진-
dc.contributor.AlternativeAuthor윤연이-
dc.contributor.AlternativeAuthor오일영-
dc.contributor.AlternativeAuthor윤창환-
dc.contributor.AlternativeAuthor서정원-
dc.contributor.AlternativeAuthor조영석-
dc.contributor.AlternativeAuthor윤태진-
dc.contributor.AlternativeAuthor채인호-
dc.contributor.AlternativeAuthor최동주-
dc.identifier.doi10.1186/s12933-017-0650-3-
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2018-01-14T04:18:33Z-
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