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Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils

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dc.contributor.authorKim, Y-K-
dc.contributor.authorOh, S-Y-
dc.contributor.authorOh, H-B-
dc.contributor.authorChun, S-Y-
dc.contributor.authorCho, S-H-
dc.contributor.authorKoh, Y-Y-
dc.contributor.authorMin, K-U-
dc.contributor.authorKim, Y-Y-
dc.date.accessioned2009-11-23T06:50:13Z-
dc.date.available2009-11-23T06:50:13Z-
dc.date.issued2002-05-08-
dc.identifier.citationClin Exp Allergy. 2002 May;32(5):751-5.en
dc.identifier.issn0954-7894 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11994101-
dc.identifier.urihttps://hdl.handle.net/10371/13869-
dc.description.abstractBACKGROUND: Our previous work on linkage analysis showed that histamine release from basophils to anti-IgE stimuli was linked to the gene marker of chromosome 11q13, where the beta chain of the high-affinity receptor for IgE (FcepsilonRI-beta) is located. OBJECTIVE: To evaluate the association between FcepsilonRI-mediated histamine release from basophils and four bi-allelic single nucleotide polymorphisms of the FcepsilonRI-beta gene. METHODS: Phenotypes of asthma, such as maximal histamine release from basophils and atopy, were measured from 80 randomly recruited asthmatic children. Polymorphisms of the FcepsilonRI-beta gene were determined by PCR-based methods. RESULTS: The polymorphism in exon 7, resulting in Glu to Gly substitution, was significantly associated with histamine release from basophils to anti-IgE stimuli, but not with total IgE levels and skin test responses to aeroallergens. CONCLUSION: This study supports a role for the FcepsilonRI-beta gene in the expression of high affinity IgE receptor-mediated histamine release from basophils.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.subjectAdolescenten
dc.subjectAllelesen
dc.subjectAsthma/*geneticsen
dc.subjectBasophils/*immunology/metabolismen
dc.subjectCalcimycin/pharmacologyen
dc.subjectChilden
dc.subjectFemaleen
dc.subjectHistamine Release/drug effects/physiologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectRandom Allocationen
dc.subjectReceptors, IgE/*genetics/*physiologyen
dc.titleCoding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophilsen
dc.typeArticleen
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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