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The fusion allele of the FUT2 (secretor type alpha(1,2)-fucosyltransferase) gene at a high frequency and a new se385 allele in a Korean population

Cited 9 time in Web of Science Cited 10 time in Scopus
Authors
Park, Kyoung Un; Song, Junghan; Han, Kyou Sup; Kim, Jin Q
Issue Date
2005-04-06
Publisher
Springer International
Citation
Ann Hematol. 2005 Oct;84(10):656-60. Epub 2005 Apr 5.
Keywords
*AllelesFemaleFucosyltransferases/*geneticsGene Frequency/*geneticsGene Fusion/*geneticsGenetics, PopulationHumansKoreaMalePolymerase Chain Reaction/methods*Polymorphism, Restriction Fragment Length
Abstract
The fusion gene (se(fus)), a nonfunctional allele of the FUT2 [secretor type alpha(1,2)-fucosyltransferase] gene, was found in Japanese populations with high frequencies (4.8-7.9%). In a study on a Korean population, se(fus) was found at a very low frequency (0.6%), but it has not yet been revealed in any other ethnic population. The aim of the present study was to investigate FUT2 gene polymorphisms in a Korean population and to evaluate their implications in secretor expression in saliva. We investigated the frequency of the FUT2 alleles in a Korean population via polymerase chain reaction with confronting two-pair primers (PCR-CTPP) and restriction fragment length polymorphism (PCR-RFLP). Blood samples were collected from 348 random donors in Bundang Koreans. From a total of 696 alleles examined, the frequency of the se(fus) allele in the Korean population was 10.8%. In addition, the new se385 allele was found in about 7.2% of the subjects, an unusually frequent occurrence compared to any other population investigated so far. The null alleles of the FUT2 gene are another example of rare alleles occurring with unexpectedly high frequencies in distinct geographic regions or populations.
ISSN
0939-5555 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15809881

https://hdl.handle.net/10371/13870
DOI
https://doi.org/10.1007/s00277-005-1041-5
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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