Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition

Cited 37 time in Web of Science Cited 46 time in Scopus

Hassan, Sonia S; Romero, Roberto; Tarca, Adi L; Draghici, Sorin; Pineles, Beth; Bugrim, Andrej; Khalek, Nahla; Camacho, Natalia; Mittal, Pooja; Yoon, Bo Hyun; Espinoza, Jimmy; Kim, Chong Jai; Sorokin, Yoram; Malone, John Jr

Issue Date
Am J Obstet Gynecol. 2007 Sep;197(3):250.e1-7.
Cervix Uteri/*physiologyCesarean SectionCross-Sectional StudiesFemaleHumansLabor, Obstetric/*geneticsPregnancySignal Transduction/*geneticsTerm Birth/*geneticsGene Expression Profiling
OBJECTIVE: This study aimed to discover "signature pathways" that characterize biologic processes, based on genes differentially expressed in the uterine cervix before and after spontaneous labor. STUDY DESIGN: The cervical transcriptome was characterized previously from biopsy specimens taken before and after term labor. Pathway analysis was used to study the differentially expressed genes, based on 2 gene-to-pathway annotation databases (Kyoto Encyclopedia of Genes and Genomes [Kanehisa Laboratories, Kyoto University, Kyoto, Japan] and Metacore software [GeneGo, Inc, St. Joseph, MI]). Overrepresented and highly impacted pathways and connectivity nodes were identified. RESULTS: Fifty-two pathways in the Metacore database were enriched significantly in differentially expressed genes. Three of the top 5 pathways were known to be involved in cervical remodeling. Two novel pathways were plasmin signaling and plasminogen activator urokinase signaling. The same analysis with the Kyoto Encyclopedia of Genes and Genomes database identified 4 significant pathways that the impact analysis confirmed. Multiple nodes that provide connectivity within the plasmin and plasminogen activator urokinase signaling pathways were identified. CONCLUSION: Three strategies for pathway analysis were consistent in their identification of novel, unexpected, and expected pathways, which suggests that this approach is both valid and effective for the elucidation of biologic mechanisms that are involved in cervical dilation and remodeling.
1097-6868 (Electronic)
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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