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The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

Cited 13 time in Web of Science Cited 13 time in Scopus
Authors
Baek, Keumjin; Choi, Youngnim
Issue Date
2017-09
Publisher
WILEY-BLACKWELL
Citation
Molecular Oral Microbiology, Vol.33 No.1, pp.22-28
Keywords
The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?복합학bacteriacausalityfungioral lichen planusviruses
Abstract
Oral lichen planus (OLP) is a variant of lichen planus (LP), a common chronic mucocu-taneous inflammatory disease. Cutaneous lesions of LP are self- limiting, but OLP le-sions are non- remissive, alternating periods of exacerbation and quiescence, and only symptomatic treatments exist for OLP. The precise etiology and pathogenesis of OLP are hardly understood, which is a major obstacle to the development of new therapeu-tics for this disease. OLP is considered a T- cell- mediated inflammatory disease. Although various antigens have been considered, what actually triggers the inflamma-tory response of T cells is unknown. Suggested predisposing factors include genetic factors, stress, trauma, and infection. The aim of this review was to determine whether microbial infection can cause OLP. We first reviewed the association between OLP and microbial factors, including viral, fungal, and bacterial infections. In addition, each microbial factor associated with OLP was assessed by modified guidelines of Fredricks and Relman to determine whether it establishes a causal relationship. In conclusion, no microbial factor yet fulfills the guidelines to establish the causality of OLP. By focusing on the unclarified issues, however, the potential roles of microbial factors in the patho-genesis of OLP will be soon elucidated.
ISSN
2041-1006
Language
English
URI
http://hdl.handle.net/10371/139278
DOI
https://doi.org/10.1111/omi.12197
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dental Research Institute (치학연구소)Journal Papers (저널논문_치학연구소)
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