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Effects of dietary supplementation of a lipid-coated zinc oxide product on the fecal consistency, growth, and morphology of the intestinal mucosa of weanling pigs

Cited 6 time in Web of Science Cited 5 time in Scopus
Authors

Byun, Young-Jin; Lee, Chul Young; Kim, Myeong Hyeon; Jung, Dae Yun; Han, Jeong Hee; Jang, Insurk; Song, Young Min; Park, Byung-Chul

Issue Date
2018-01-30
Publisher
BioMed Central
Citation
Journal of Animal Science and Technology, 59(1):29
Keywords
Weaned pigZincGrowthDiarrheaIntestine
Abstract
Background

Dietary supplementation of zinc oxide (ZnO) to 2000 to 4000mg/kg is known to be effective for the prevention and treatment of post-weaning diarrhea in the pig. Such a pharmacological supplementation, however, can potentially result in environmental pollution of the heavy metal, because dietary ZnO is mostly excreted unabsorbed. Two experiments (Exp.) were performed in the present study to determine the effects of a lipid-coated ZnO supplement Shield Zn (SZ) compared with those of ZnO.

Methods
In Exp. 1, a total of 240 21-day-old weanling pigs were fed a diet supplemented with 100mg Zn/kg as ZnO (ZnO-100), ZnO-2500, SZ-100, or SZ-200 in 24 pens for 14days on a farm with its post-weaning pigs exhibiting a low incidence of diarrhea. Exp. 2 was performed using 192 24-day-old piglets as in Exp. 1 on a different farm, which exhibited a high incidence of diarrhea.

Results
In Exp. 1, fecal consistency (diarrhea) score (FCS) was less for the ZnO-2500 and SZ-200 groups than for the SZ-100 group (P < 0.05), with no difference between the SZ-100 and ZnO-100 groups. Both average daily gain (ADG) and gain:feed ratio were less for the SZ-200 group than for the ZnO-2500 group, with no difference between the ZnO-100 group and SZ-100 or SZ-200 group. The villus height (VH), crypt depth (CD), and VH:CD ratio of the intestinal mucosa were not influenced by the treatment. In Exp. 2, FCS was lowest for the ZnO-2500 group, with no difference among the other groups. However, neither the ADG nor gain:feed ratio was influenced by the treatment.

Conclusion
Results suggest that physiological SZ supplementation has less beneficial effects than pharmacological ZnO for the alleviation of diarrhea irrespective of its severity and for promoting growth without influencing their integrity of the intestinal mucosal structures with little advantage over physiological ZnO in weanling pigs with a small pen size.
ISSN
2049-1891
Language
English
URI
https://hdl.handle.net/10371/139577
DOI
https://doi.org/10.1186/s40781-017-0159-z
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