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A phase II trial of S-1 and oxaliplatin in patients with advanced hepatocellular carcinoma

Cited 6 time in Web of Science Cited 6 time in Scopus
Issue Date
2018-03
Publisher
BioMed Central
Citation
BMC Cancer, Vol.18 No.1, p. 252
Keywords
Hepatocellular carcinomaChemotherapyPhase IIOxaliplatinS-1
Abstract
Background: Oxaliplatin is a platinum derivative that has shown efficacy in advanced hepatocellular carcinoma. S-1 is an oral fluoropyrimidine that has substituted for 5-fluorouracil in many cancers. This was a multicenter, openlabel, single-arm phase II trial that evaluated the efficacy of S-1 and oxaliplatin (SOX) in advanced hepatocellular carcinoma. All patients included in the present study were systemic treatment-naive. Prior treatment with sorafenib was allowed, but other treatments were not. Methods: Patients received S-1 (40 mg/m(2) twice daily from day 1-14) and oxaliplatin (130 mg/m(2) on day 1) every 3 weeks. The primary end point was time to progression (TTP). Secondary end points included progression-free survival, overall survival (OS), response rate, and safety profile. Results: Thirty six patients with advanced hepatocellular carcinoma were included in this study. The median TTP was 3. 0 months (95% confidence interval (CI), 0.75-5.25), and the median OS was 10.3 months (95% CI, 6.4-14.3). Bone metastasis was associated with poorer TTP and OS. The efficacy of SOX was unaffected by prior sorafenib or locoregional therapy. The objective response rate was 13.9%. No grade 4 toxicity or death from adverse events occurred. The most common grade 3 toxicities were neutropenia (13.9%), thrombocytopenia (13.9%), and diarrhea (8.3%). Conclusions: Although this trial did not meet its primary end point, the SOX regimen showed comparable efficacy and safety to the 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) regimen. As the SOX regimen is easier for patients, SOX may be a reasonable substitute for FOLFOX in hepatocellular carcinoma.
ISSN
1471-2407
Language
English
URI
https://hdl.handle.net/10371/139656
DOI
https://doi.org/10.1186/s12885-018-4039-9
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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