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Reconstruction and Validation of the 12-Lead Electrocardiogram from 3-lead Patch-type Device : 패치형 3-리드 심전도 장치를 통해 재구축한 12-유도 심전도의 임상적 유용성에 대한 연구

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dc.contributor.advisor김희찬-
dc.contributor.author손장재-
dc.date.accessioned2018-05-29T03:38:31Z-
dc.date.available2018-05-29T03:38:31Z-
dc.date.issued2018-02-
dc.identifier.other000000149656-
dc.identifier.urihttps://hdl.handle.net/10371/141610-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 공과대학 협동과정 바이오엔지니어링전공, 2018. 2. 김희찬.-
dc.description.abstractThe 12-lead electrocardiogram (ECG) is a vital diagnostic tool for cardiologists. A conventional 12-lead system is desirable to obtain full information from ECG, as different kinds of information can be obtained from different locations of leads. The standard 12-lead system requires 10 electrodes to be attached on a wide bare area of the human body. However, to be applied in a mobile system, a reduced number of electrodes is mandatory-
dc.description.abstractin addition, lead positions should be close enough to be put in a patch system. For these reasons, we propose the 3-lead patch-type ECG device. With the signals obtained from the device, we synthesized 12-lead ECG by personal transformation and by universal transformation, equation that was established in 15 normal subjects.
These reconstructed ECGs were compared with standard 12-lead ECG. Measurements of normal parameters in standard, personal and universal transformation ECG were compared in 10 normal subjects. The total QRS voltage in universal transformation was significantly lower than that in standard ECG (p<0.04). No statistically significant differences were observed among the normal parameters except in the case of the total QRS voltage.
The diagnostic sensitivity and specificity of personalized and universal transformation ECG were tested in 38 patients with pathologic findings in ECG (LVH: 14, wide QRS (≥ 120 ms): 6, pathologic Q : 6, ST elevation : 7, ST depression : 10, T inversions: 9). Both personalized and universal transformation ECG are sensitive and specific in the detection of the alteration in the direction of electric vectors as pathologic Q and T inversions, but are insensitive in the detection of small changes in the magnitude of electric vectors as ST changes. Personalized and universal transformation ECG were sensitive in detecting wide QRS complex
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dc.description.abstracthowever, there were false positive cases with specificity of 77% and 79%, respectively.
Reconstruction of 12-lead ECG using a 3-lead patch-type device is feasible, valid in the measurements of normal parameters and can provide additional information compared to the single lead-ECG. However, further study is needed to increase the sensitivity of detecting ST changes and to overcome the problem of false positive wide QRS complexes.

Keyword: Patch-type device, synthesized ECG, Pathologic ECG
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dc.description.tableofcontents1. Introduction 1
1.1. Clinical importance of ECG and ECG monitoring 1
1.2. Lead systems in ECG monitoring 2
1.3 Clinical needs for the number and location of electrodes 3
1.4. Theoretical aspect 4
2. Method 4
2.1 Mobile ECG system design 4
2.2. Hardware 5
2.3 Software 7
2.3.1 Data acquisition system 7
2.3.2 Data analysis program 8
2.3.2.1 Establishment of personal and universal transformation 10
2.4 Enrollment of subjects 11
2.4.1 Informed consent 11
2.4.2 Normal subjects 11
2.4.3 Subjects with pathologic ECG findings 11
2.4.3.1 ECG showing ST depression 11
2.4.3.2. Pathologic findings other than ST depression 11
2.5 Statistics 12
3. Results 12
3.1 Feasibility personalized and universal transformations 12
3.2. ECG parameters in normal subjects 13
3.3. Clinical validity in pathologic ECG 14
3.3.1 LVH 15
3.3.2 ST changes 16
3.3.2.1 False negative 16
3.3.2.2 False positive 16
3.3.3 Wide QRS 19
4. Discussion 20
5. Conclusion 24
6. References 25
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dc.formatapplication/pdf-
dc.format.extent2019707 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subject심전도 자동 분석-
dc.subject패치형 심전계-
dc.subject합성 12유도 심전도-
dc.subject병적 심전도-
dc.subject.ddc660.6-
dc.titleReconstruction and Validation of the 12-Lead Electrocardiogram from 3-lead Patch-type Device-
dc.title.alternative패치형 3-리드 심전도 장치를 통해 재구축한 12-유도 심전도의 임상적 유용성에 대한 연구-
dc.typeThesis-
dc.description.degreeMaster-
dc.contributor.affiliation공과대학 협동과정 바이오엔지니어링전공-
dc.date.awarded2018-02-
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