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Web Portal for the assay analytical validation of biomarkers abided by multinational integrative guidelines
다기관 가이드라인 준수 바이오마커 분석 검증 웹포탈

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Authors
김재년
Advisor
김영수
Major
공과대학 협동과정 바이오엔지니어링전공
Issue Date
2018-02
Publisher
서울대학교 대학원
Keywords
Method ValidationPortalDatabaseBiomarkerProteomicsMRM
Description
학위논문 (석사)-- 서울대학교 대학원 : 공과대학 협동과정 바이오엔지니어링전공, 2018. 2. 김영수.
Abstract
Multiple reaction monitoring mass spectrometry (MRM-MS) involves monitoring a multiplexed assay of peptides and associated transitions in mass spectrometry runs. Implemented as a freely available, open-source tool in the platform independent Java programing language, assay Portal computes analytical measures as recommended integrated multinational guidelines – that is clinical assays. Computed measures include
calibration curve, specificity, selectivity, interference, sensitivity, carryover, precision, accuracy, quality control samples, matrix effect, recovery, dilution integrity, and stability. Assay Portal streamlines assay development analytical workflow and therefore minimizes error predisposition. Assay Portal may also be used for performance estimation for MRM-MS assays. Assay Portal is available from http://pnbvalid.snu.ac.kr with sign up procedure only available by manual confirmation.
Language
English
URI
https://hdl.handle.net/10371/141613
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College of Engineering/Engineering Practice School (공과대학/대학원)Program in Bioengineering (협동과정-바이오엔지니어링전공)Theses (Master's Degree_협동과정-바이오엔지니어링전공)
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