Chemical Constituents from Cudrania tricuspidata
꾸지뽕나무의 화학 성분
- 약학대학 약학과
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과, 2018. 2. 김진웅.
- Cudrania tricuspidata Bureau, belonging to Moraceae family, is mainly distributed in Korea, Japan and China. Leaves of C. tricuspidata have been used for eczema, mumps, tuberculosis as a traditional medicine. Phytochemical studies revealed that major constituents of this plant are various types of flavonoids xanthones.
The leaves and twigs of C. tricuspidata were extracted with 100% methanol. The extract was suspended in H2O and the subsequently fractionated with n-hexane, CHCl3, EtOAc and n-BuOH. Thirty compounds were isolated from EtOAC, n-BuOH by various chromatographic techniques. Structure of compounds was elucidated based on NMR, MASS and FT-IR spectroscopic data. Compounds were identified as 4ꞌ-glucopyranosyloxybenzyl-4-O-β-D-glucopyranosyloxy-3,5-dimethoxybenzoate (1), Bis [4-O-β-D-glucopyranosyloxy)benzyl] 3-hydroxy-3-methylglutarate (2), Gastrodin (3), p-hydroxybenzaldehyde-4-O-β-D-glucopyranoside (4), 3,4,5-trimethoxy phenyl-1-O-β-D-glucopyranoside (5), Cudrabibenzyl A (6), (6S, 9R)-Roseoside (7), 3-O-caffeoyl-2-C-methyl-D-erythrono-1,4-lactone (8), Chlorogenic acid (9) Umbelliferone (10), Skimmin (11), Esculin (12), C-veratroylglycol (13), 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one (14), 4-hydroxy benzoic acid (15), Methyl-4-hydroxy benzoate (16), Quercetin (17), Quercetin-3-O-β-D-glucopyranoside (18), Quercetin-7-O-β-D-glucopyranoside (19), Kaempferol-7-O-β-D-glucopyranoside (20), Nicotiflorin (21), Aromadendrin (22), Aromadendrin-7-O-β-D-glucopyranoside (23), Gericudranin E (24), Taxifolin (25), Dihydromorin (26), Orobol (27), Orobol-7-O-β-D-glucopyranoside (28), Ambocin (29), 5-methoxy-8-glucopyranosyl-genistein (30). Compounds 1-5 were phenolic type, compound 6 was stilbenoid type, compound 7 was megastigmane derivative, compounds 8-9 were caffeoyl derivatives, compounds 10-12 were coumarin type, compounds 13-14 were phenylpropanoid type, compounds 15-16 were benzoic acid derivatives, compounds 17-30 were flavonoid type. Among them, compounds 1 and 2 were newly reported in nature. Compounds 3, 4, 5, 13, 14, 15, 16, 29 were newly reported from Moraceae family. Compounds 7, 11, 12 were newly reported from Cudrania genus.