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Sensitive determination of nonsteroidal anti-inflammatory drugs using 3-phase direct immersion single drop microextraction in-line coupled with capillary electrophoresis : 비스테로이드성 소염진통제의 분석감도 개선을 위한 미세방울 추출법과 연동된 모세관 전기영동법
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 정두수 | - |
dc.contributor.author | 최지은 | - |
dc.date.accessioned | 2018-05-29T05:12:13Z | - |
dc.date.available | 2018-05-29T05:12:13Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.other | 000000149475 | - |
dc.identifier.uri | https://hdl.handle.net/10371/142494 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 자연과학대학 화학부, 2018. 2. 정두수. | - |
dc.description.abstract | A direct immersion (DI)-single drop microextraction (SDME) in the 3-phase mode was in-line coupled with capillary electrophoresis to improve the detection sensitivity for weakly acidic nonsteroidal anti-inflammatory drugs, such as ketoprofen, ibuprofen, and naproxen in solution. The acidic analytes in an acidified sample donor solution were extracted into a basic acceptor drop covered with a thin organic layer attached to the tip of a separation capillary. Due to the small dimensions of the acceptor and the organic phases, quite high enrichment factors of 1,600-2,600 were obtained from a 10-min DI-SDME at 25°C with stirring. The limits of detections obtained by monitoring the absorbance at 214 nm were about 0.9-3 nM. | - |
dc.description.tableofcontents | 1 INTRODUCTION 1
2 MATERIALS AND METHODS 2 2.1 Reagents 2 2.2 Capillary electrophoresis 3 2.3 3-Phase direct immersion single drop microextraction 4 3 RESULT AND DISCUSSION 5 3.1 Donor and acceptor phases 5 3.2 Octanol layer 6 3.3 Agitation of the samples 7 3.4 Extraction time 7 3.5 Analytical performance 8 4 CONCLUDING REMARKS 9 REFERENCES 10 | - |
dc.format | application/pdf | - |
dc.format.extent | 424638 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Single drop microextraction | - |
dc.subject | Capillary electrophoresis | - |
dc.subject | Direct immersion | - |
dc.subject | Nonsteroidal anti-inflammatory drugs | - |
dc.subject.ddc | 540 | - |
dc.title | Sensitive determination of nonsteroidal anti-inflammatory drugs using 3-phase direct immersion single drop microextraction in-line coupled with capillary electrophoresis | - |
dc.title.alternative | 비스테로이드성 소염진통제의 분석감도 개선을 위한 미세방울 추출법과 연동된 모세관 전기영동법 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 자연과학대학 화학부 | - |
dc.date.awarded | 2018-02 | - |
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