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Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014

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dc.contributor.authorKim, Ju Whi-
dc.contributor.authorLee, Kyung Jae-
dc.contributor.authorYang, Hye Ran-
dc.contributor.authorChang, Ju Young-
dc.contributor.authorMoon, Jin Soo-
dc.contributor.authorKhang, Young-Ho-
dc.contributor.authorKo, Jae Sung-
dc.date.accessioned2018-05-31T05:38:52Z-
dc.date.available2018-05-31T14:42:48Z-
dc.date.issued2018-05-11-
dc.identifier.citationBMC Public Health, 18(1):617ko_KR
dc.identifier.issn1471-2458-
dc.identifier.urihttps://hdl.handle.net/10371/142660-
dc.description.abstractBackground
An elevated alanine aminotransferase (ALT) level is a surrogate marker of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in adolescents. The majority of previous NAFLD studies in adolescents were performed in selected obese populations or had a cross-sectional design without a time-trend analysis. The purpose of this study was to estimate the prevalence and time trends of elevated ALT levels in a general adolescent population and to identify factors associated with ALT elevation.

Methods
We analysed data of adolescent participants (aged 10–18years) from the Korean National Health and Nutrition Examination Survey 2001–2014, a representative sample of the general population in South Korea. Suspected NAFLD was defined as ALT elevation (> 30U/L) without hepatitis B surface antigen. In all statistical analyses, sampling weight- and design-based data were used.

Results
ALT was elevated in 5.3% (standard error: 0.3%) of the study population of adolescent participants (N = 8455). No significant trends were found from 2001 to 2014 in the prevalence of elevated ALT among male and female adolescents. In multiple logistic regression analysis, elevated ALT was independently associated with sex (odds ratio [OR] male versus female 4.5; 95% CI, 3.3-6.2), obesity (OR 7.6; 95% CI, 5.3-11.0), and truncal obesity (OR 2.5; 95% CI, 1.8-3.5). Furthermore, male sex, obesity, truncal obesity and high household income level were associated with log-transformed ALT levels in multiple regression analysis.

Conclusions
In Korean adolescents of both genders, the prevalence of elevated ALT levels was stable from 2001 to 2014. This study has revealed that sex, obesity, truncal obesity and household income level are associated with ALT elevation in adolescents.
ko_KR
dc.description.sponsorshipThis study was supported by grants from the Seoul National University Hospital Research Fund.ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectAlanine aminotransferaseko_KR
dc.subjectPrevalenceko_KR
dc.subjectFatty livereko_KR
dc.titlePrevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014ko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김주휘-
dc.contributor.AlternativeAuthor이경재-
dc.contributor.AlternativeAuthor양혜란-
dc.contributor.AlternativeAuthor장주영-
dc.contributor.AlternativeAuthor문진수-
dc.contributor.AlternativeAuthor강영호-
dc.contributor.AlternativeAuthor고재성-
dc.identifier.doi10.1186/s12889-018-5548-9-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2018-05-13T03:36:05Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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