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Numerical study of entrainment of the human circadian system and recovery by light treatment

Cited 2 time in Web of Science Cited 3 time in Scopus
Authors

Kim, Soon Ho; Goh, Segun; Han, Kyungreem; Kim, Jong Won; Choi, MooYoung

Issue Date
2018-05-09
Publisher
BMC
Citation
Theoretical Biology and Medical Modelling, 15(1):5
Keywords
Mathematical model of sleepCircadian rhythmEntrainmentOrexin
Abstract
Background
While the effects of light as a zeitgeber are well known, the way the effects are modulated by features of the sleep-wake system still remains to be studied in detail.

Methods
A mathematical model for disturbance and recovery of the human circadian system is presented. The model combines a circadian oscillator and a sleep-wake switch that includes the effects of orexin. By means of simulations, we characterize the period-locking zone of the model, where a stable 24-hour circadian rhythm exists, and the occurrence of circadian disruption due to both insufficient light and imbalance in orexin. We also investigate how daily bright light treatments of short duration can recover the normal circadian rhythm.

Results
It is found that the system exhibits continuous phase advance/delay at lower/higher orexin levels. Bright light treatment simulations disclose two optimal time windows, corresponding to morning and evening light treatments. Among the two, the morning light treatment is found effective in a wider range of parameter values, with shorter recovery time.

Conclusions
This approach offers a systematic way to determine the conditions under which circadian disruption occurs, and to evaluate the effects of light treatment. In particular, it could potentially offer a way to optimize light treatments for patients with circadian disruption, e.g., sleep and mood disorders, in clinical settings.
ISSN
1742-4682
Language
English
URI
https://hdl.handle.net/10371/142662
DOI
https://doi.org/10.1186/s12976-018-0077-x
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