Publications
Detailed Information
A clinical study to investigate the effect of multidrug and toxin extrusion transporter inhibitor on pharmacokinetic characteristics and anti-hyperglycaemic activity of metformin : Multidrug and toxin extrusion 수송체 저해제가 메트포민의 약동학 특성 및 혈당 강하 효과에 미치는 영향 평가 연구
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 유경상 | - |
| dc.contributor.author | 오재성 | - |
| dc.date.accessioned | 2018-11-12T00:53:17Z | - |
| dc.date.available | 2018-11-12T00:53:17Z | - |
| dc.date.issued | 2018-08 | - |
| dc.identifier.other | 000000151849 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/142977 | - |
| dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의과학과, 2018. 8. 유경상. | - |
| dc.description.abstract | Introduction: Renal tubular secretion of metformin is mediated mainly via Multidrug And Toxin Extrusion (MATE) transporters at the apical membrane. We hypothesized that the anti-hyperglycaemic activity of metformin would change with inhibition of the MATE transporter.
Methods: Twenty healthy male subjects received 500 mg of metformin with and without 50 mg of pyrimethamine (a potent MATE inhibitor) twice daily, with 1 week of washout in between. The anti-hyperglycaemic activity of metformin were assessed for each period by administering the oral glucose tolerance test (OGTT) before and after the metformin dose | - |
| dc.description.tableofcontents | INTRODUCTION 1
METHODS 5 Subjects 5 Clinical study design 5 Blood and urine collection 8 Determination of metformin concentrations 8 Genotyping of MATE1, MATE2-K and OCT2 9 Pharmacodynamics data analysis from the OGTT 10 Pharmacokinetics data analysis 11 Serum and urine creatinine data analysis 13 Statistical analysis 13 RESULTS 15 Effects of MATE inhibition on systemic exposure to metformin 15 Effect of MATE inhibition on the glucose-lowering effect of metformin 19 Effects of MATE inhibition on the serum creatinine and creatinine clearance 24 Effects of MATE1, MATE2-K and OCT2 genotype on the drug-drug interaction between the pyrimethamine and the metformin 26 DISCUSSION 39 REFERENCES 47 APPENDICES 59 국문 초록 75 | - |
| dc.language.iso | en | - |
| dc.publisher | 서울대학교 대학원 | - |
| dc.subject.ddc | 610.72 | - |
| dc.title | A clinical study to investigate the effect of multidrug and toxin extrusion transporter inhibitor on pharmacokinetic characteristics and anti-hyperglycaemic activity of metformin | - |
| dc.title.alternative | Multidrug and toxin extrusion 수송체 저해제가 메트포민의 약동학 특성 및 혈당 강하 효과에 미치는 영향 평가 연구 | - |
| dc.type | Thesis | - |
| dc.description.degree | Doctor | - |
| dc.contributor.affiliation | 의과대학 의과학과 | - |
| dc.date.awarded | 2018-08 | - |
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.