An integrated clinical and genomic information system for cancer precision medicine

Abstract

The increasing affordability of next-generation sequencing (NGS) has enabled the implementation of genomically-informed personalized cancer therapy as a path to precision oncology. However, the complex nature of genomic information renders it challenging for clinicians to interpret the patient's genomic alterations and select the optimum approved or investigational therapy. Thus, an elaborate and practical information system is urgently needed to support clinical decision and to rapidly test clinical hypotheses.<br/> Molecular alterations in a set of genes, including somatic mutations, copy number variations, and gene expression levels, represent a novel signature in targeted cancer therapy