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Enhancer Prediction with Histone Modification Marks Using a Hybrid Neural Network Model : 히스톤 변이 마크를 통한 인핸서 영역 분류 인공신경망 모델
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- Authors
- Advisor
- 김선
- Major
- 공과대학 컴퓨터공학부
- Issue Date
- 2018-08
- Publisher
- 서울대학교 대학원
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 공과대학 컴퓨터공학부, 2018. 8. 김선.
- Abstract
- An enhancer is a regulatory region in DNA, increasing transcription of a gene by combining with transcription factors. Whereas a promoter is located near a transcription start site, an enhancer can often be located far from a target gene, making hard to identify enhancer regions in DNA. Therefore, many researches in Bioinformatics have challenged to classify enhancer region computationally. In this paper, a hybrid neural network, Convolutional Neural Network followed by Recurrent Neural Network, are used for classifying enhancer regions in DNA with histone modification marks input and my model showed high performance in evaluation. With the trained model, optimizing virtual input matrix can give insight into how histone modification marks represent enhancer regions.
- Language
- English
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