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Isolation and Structure Determination of Bioactive Constituents from Poncirus trifoliata Raf. : 지실의 성분연구
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 신종헌 | - |
| dc.contributor.author | 이원희 | - |
| dc.date.accessioned | 2018-12-03T01:45:49Z | - |
| dc.date.available | 2021-09-23T06:06:41Z | - |
| dc.date.issued | 2018-08 | - |
| dc.identifier.other | 000000152331 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/143939 | - |
| dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과, 2018. 8. 신종헌. | - |
| dc.description.abstract | Abstract
Isolation and Structure Determination of Bioactive Constituents from Poncirus trifoliata Raf. Won-Hee Lee Natural Products Science Major College of Pharmacy Master Course in the Graduate School Seoul National University Sortase A (SrtA), a gram-positive transpeptidase, is an important target in reducing bacterial infection. The extract from the fruits of trifoliate orange, Poncirus trifoliata Rafinesque, showed significant Srt A inhibition. Poncirus trifoliata Raf. is a member of the family Rutaceae and it has been widely used in Korean traditional medicine for the treatment of diverse pathogenic symptoms. Bioactivity-guided chromatographic separation afforded the isolation of in total twelve compounds, eight coumarins and four flavanone glycosides. The structures of four novel coumarins were determined by a combination of spectroscopic analyses such as NMR and LC-MS. The absolute configurations of the new coumarins and known coumarins, previously unassigned, were determined by an application of the 2-methoxy-2-(trifluoromethyl)phenylacetic acid (MTPA) method. Key words: herbal medicine, Poncirus trifoliata Rafinesque, coumarins, flavanone glycosides, sortase A inhibition Student number: 2016-29626 | - |
| dc.description.tableofcontents | Introduction . 1
Experimental Section 3 1. General Experimental Procedures 3 2. Plant Material . 3 3. Extraction and Isolation 4 4. Preparation of the (S)- and (R)-α-Methoxy-αtrifluoromethylphenylacetic chloride (MTPA-Cl) Esterification of Compound 1-6 6 Results . 12 1. Compound 1 . 12 2. Compound 2 . 12 3. Compound 3 . 13 4. Compound 4 . 13 5. Compound 5 . 14 6. Compound 6 . 14 7. Compound 7 . 15 8. Compound 8 . 15 9. Compound 9 . 16 10. Compound 10 . 16 11. Compound 11 16 12. Compound 12 . 17 Discussion 40 References . 41 Abstract in Korean . 75 | - |
| dc.format | application/pdf | - |
| dc.format.medium | application/pdf | - |
| dc.language.iso | en | - |
| dc.publisher | 서울대학교 대학원 | - |
| dc.subject.ddc | 615 | - |
| dc.title | Isolation and Structure Determination of Bioactive Constituents from Poncirus trifoliata Raf. | - |
| dc.title.alternative | 지실의 성분연구 | - |
| dc.type | Thesis | - |
| dc.description.degree | Master | - |
| dc.contributor.affiliation | 약학대학 약학과 | - |
| dc.date.awarded | 2018-08 | - |
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