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The impact of sunlight exposure on mortality of ESRD patients: Comparison of the results using case-crossover study design : 일조시간이 말기신부전(ESRD) 환자의 사망에 미치는 영향: Case-crossover design을 이용한 결과비교
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김호 | - |
dc.contributor.author | 윤은아 | - |
dc.date.accessioned | 2018-12-03T01:55:31Z | - |
dc.date.available | 2020-10-06T07:22:17Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.other | 000000152640 | - |
dc.identifier.uri | https://hdl.handle.net/10371/144210 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 보건대학원 보건학과(보건학전공), 2018. 8. 김호. | - |
dc.description.abstract | Background
Recent data suggest that reduced sunlight exposure is associated with increased mortality in the general population. To date, the association between sunlight exposure and mortality in dialysis patients has not been examined. Objective Among 134,478 dialysis patients in the Korean end-stage renal disease (ESRD) cohort from 2001 to 2014, 31,291 patients were enrolled from seven metropolitan cities, and data were analyzed using bi-directional case-crossover design. We examined the association between short-term sunlight exposure and mortality in ESRD patients. We adjusted for temperature, humidity, and daily concentrations of nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), and particle matter (PM10) as confounders. Method Among 134,478 dialysis patients in the Korean end-stage renal disease (ESRD) cohort from 2001 to 2014, 31,291 patients were enrolled from seven metropolitan cities, and data were analyzed using bi-directional case-crossover design. We examined the association between short-term sunlight exposure and mortality in ESRD patients. We adjusted for temperature, humidity, and daily concentrations of nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), and particle matter (PM10) as confounders. Result The characteristics of the study population included age (65.6 ± 12.26 (mean ± standard deviation [SD]) years), sex (male, 59.96% | - |
dc.description.abstract | female, 41.04%), comorbidity (diabetes, 53.58% | - |
dc.description.abstract | hypertension, 40.5%), and kidney dialysis type (hemodialysis, 73.02% | - |
dc.description.abstract | peritoneal dialysis, 26.98 %). The mean ± SD follow-up time was 4.68 ± 4.37 years. The daily sunlight exposure was significantly decreased in the case group compared with the control group (P=0.004). Sunlight exposure was associated with all-cause death overall (ORs [95%CI]: 0.99 [0.98-0.99], P=0.042) in a fully adjusted model. Patients with diabetes (ORs [95%CI]: 0.98 [0.97-0.99], P=0.016) or aged higher than 75 years (ORs [95%CI] | - |
dc.description.abstract | 0.97 [0.96 – 0.99], P=0.020) had higher risks of mortality than patients without diabetes or aged below 75 years, respectively.
Conclusion These findings suggest that sunlight exposure is inversely correlated with all-cause mortality in dialysis patients, especially in high-risk patients with diabetes and older adults. Keyword : sunlight exposure, mortality, end stage renal disease, ESRD, sunshine vitamin, vitamin D | - |
dc.description.tableofcontents | Abstract 2
Chapter 1. Introduction 7 Chapter 2. Method 9 2.1. Study population 9 2.2. Weather and air pollution data 10 2.3. Study design 10 2.4. Statistical analysis 12 Chapter 3. Result 15 3.1. Descriptive results 15 3.2. Effect modification by meteorological and air pollution factors 21 3.3. Difference in daily levels of environmental variables between case and control periods(2001-2014) 22 3.4. Effect of sunlight exposure on ESRD death 24 3.5. Comparison of the results in Case-crossover designs 26 Chapter 4. Discussion 30 Reference 36 | - |
dc.format | application/pdf | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 614 | - |
dc.title | The impact of sunlight exposure on mortality of ESRD patients: Comparison of the results using case-crossover study design | - |
dc.title.alternative | 일조시간이 말기신부전(ESRD) 환자의 사망에 미치는 영향: Case-crossover design을 이용한 결과비교 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Una Amelia Yoon | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 보건대학원 보건학과(보건학전공) | - |
dc.date.awarded | 2018-08 | - |
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