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Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Hyuck-Joo | - |
dc.contributor.author | Oh, Ye-In | - |
dc.contributor.author | Jeong, Jong-Woo | - |
dc.contributor.author | Song, Kun-Ho | - |
dc.contributor.author | Koo, Tae-Sung | - |
dc.contributor.author | Seo, Kyoung-Won | - |
dc.date.accessioned | 2018-12-14T05:25:56Z | - |
dc.date.available | 2018-12-14T14:26:59Z | - |
dc.date.issued | 2018-09-24 | - |
dc.identifier.citation | BMC Veterinary Research, 14(1):291 | ko_KR |
dc.identifier.issn | 1746-6148 | - |
dc.identifier.uri | https://hdl.handle.net/10371/144953 | - |
dc.description.abstract | Background
Sildenafil citrate, a highly selective phosphodiesterase type 5 inhibitor, is used to treat pulmonary hypertension (PH) in veterinary medicine. The objective of this study was to investigate pharmacokinetic profiles by oral administration of orally disintegrating film (ODF) and film coated tablet (FCT) formulations and rectal administration of ODF formulation in healthy dogs. Twelve healthy beagle dogs were administered four separate doses of sildenafil: FCT formulation 2mg/kg orally, ODF formulation 2mg/kg orally, ODF formulation 2mg/kg rectally, and ODF formulation 10mg/kg rectally. For 24 hours following administration, blood samples were collected and the plasma concentrations of sildenafil were assayed by liquid chromatography-tandem mass spectrometry. Results There were no significant differences in all the pharmacokinetic parameters between FCT and ODF formulations when administrated orally. Cmax at the time of rectal administration was lower when the same dose was given as that orally administered. No serious systemic adverse events (AEs) were observed. Conclusions These findings suggest that sildenafil ODF formulation can be used as an alternative to FCT formulation in the treatment of canine PH patients; additionally, rectal administration of sildenafil ODF may be a beneficial treatment option for canine patients who are unable to receive medication orally. | ko_KR |
dc.description.sponsorship | This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) and funded by the Korean government (MSIT) (No. 2017M3A9C8021844). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Dog | ko_KR |
dc.subject | Orally disintegrating film formulation | ko_KR |
dc.subject | Rectal administration | ko_KR |
dc.subject | Sildenafil | ko_KR |
dc.subject | Pulmonary hypertension | ko_KR |
dc.title | Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 양혁주 | - |
dc.contributor.AlternativeAuthor | 오예인 | - |
dc.contributor.AlternativeAuthor | 정종우 | - |
dc.contributor.AlternativeAuthor | 송건호 | - |
dc.contributor.AlternativeAuthor | 구태성 | - |
dc.contributor.AlternativeAuthor | 서경원 | - |
dc.identifier.doi | 10.1186/s12917-018-1617-7 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-09-30T03:56:14Z | - |
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