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Effect of tailored use of tirofiban in patients with Non-ST-elevation acute coronary syndrome undergoing percutaneous coronary intervention: a randomized controlled trial
Cited 2 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2018-10-22
- Publisher
- BioMed Central
- Citation
- BMC Cardiovascular Disorders, 18(1):201
- Keywords
- Glycoprotein IIb/IIIa inhibitor ; Tailored antiplatelet treatment ; Periprocedural myonecrosis ; High residual platelet activity
- Abstract
- Background
We conducted a randomized controlled trial to investigate whether an additional platelet inhibition with tirofiban would reduce the extent of myocardial damage and prevent periprocedural myonecrosis in patients with Non-ST-elevation acute coronary syndrome (NSTE-ACS) with a high residual platelet activity (HPR).
Methods
Patients with an HPR, defined as P2Y12 reaction unit (PRU) > 230, were randomly assigned to group A (tirofiban treatment, n = 30) or C1 (n = 30) and patients without an HPR to C2 (n = 78). Periprocedural myocardial damage was assessed using the area under the curve (AUC) of serial cardiac enzyme levels from the time of the procedure to post-36h. Periprocedural myonecrosis incidence was evaluated.
Results
The troponin I AUC was not different between the groups (197.2 [41.5395.7], 37.9 [8.9313.9], 121.3 [43.7481.8] h∙ng/mL; p = 0.088). The results did not change when the baseline levels were adjusted (365.3 [279.5, 451.1], 293.0 [207.1, 379.0], and 298.0 [244.7, 351.3] h∙ng/mL; p = 0.487). The rate of periprocedural myonecrosis was also not different between the groups (53.0% vs. 50.0% vs. 33.3%, p = 0.092). The CK-MB isoenzyme analysis showed similar results. No difference in complications was noted.
Conclusion
Additional tirofiban administration was not beneficial to patients with NSTE-ACS even with an HPR.
Trial registration
Clinical trial no. NCT03114995, registered 11 April, 2017, retrospectively.
- ISSN
- 1471-2261
- Language
- English
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