Browse

Effect of tailored use of tirofiban in patients with Non-ST-elevation acute coronary syndrome undergoing percutaneous coronary intervention: a randomized controlled trial

Cited 1 time in Web of Science Cited 1 time in Scopus
Authors
Lee, Wonjae; Suh, Jung-Won; Park, Jin Joo; Yoon, Chang-Hwan; Cho, Young-Seok; Youn, Tae-Jin; Chae, In-Ho
Issue Date
2018-10-22
Publisher
BioMed Central
Citation
BMC Cardiovascular Disorders, 18(1):201
Keywords
Glycoprotein IIb/IIIa inhibitorTailored antiplatelet treatmentPeriprocedural myonecrosisHigh residual platelet activity
Abstract
Background
We conducted a randomized controlled trial to investigate whether an additional platelet inhibition with tirofiban would reduce the extent of myocardial damage and prevent periprocedural myonecrosis in patients with Non-ST-elevation acute coronary syndrome (NSTE-ACS) with a high residual platelet activity (HPR).

Methods
Patients with an HPR, defined as P2Y12 reaction unit (PRU) > 230, were randomly assigned to group A (tirofiban treatment, n = 30) or C1 (n = 30) and patients without an HPR to C2 (n = 78). Periprocedural myocardial damage was assessed using the area under the curve (AUC) of serial cardiac enzyme levels from the time of the procedure to post-36 h. Periprocedural myonecrosis incidence was evaluated.

Results
The troponin I AUC was not different between the groups (197.2 [41.5395.7], 37.9 [8.9313.9], 121.3 [43.7481.8] h∙ng/mL; p = 0.088). The results did not change when the baseline levels were adjusted (365.3 [279.5, 451.1], 293.0 [207.1, 379.0], and 298.0 [244.7, 351.3] h∙ng/mL; p = 0.487). The rate of periprocedural myonecrosis was also not different between the groups (53.0% vs. 50.0% vs. 33.3%, p = 0.092). The CK-MB isoenzyme analysis showed similar results. No difference in complications was noted.

Conclusion
Additional tirofiban administration was not beneficial to patients with NSTE-ACS even with an HPR.

Trial registration
Clinical trial no. NCT03114995, registered 11 April, 2017, retrospectively.
ISSN
1471-2261
Language
English
URI
https://hdl.handle.net/10371/146855
DOI
https://doi.org/10.1186/s12872-018-0938-6
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse