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Systolic and diastolic dysfunction affects kidney outcomes in hospitalized patients
DC Field | Value | Language |
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dc.contributor.author | Choi, Jae Shin | - |
dc.contributor.author | Baek, Seon Ha | - |
dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Kim, Sejoong | - |
dc.contributor.author | Han, Seung Seok | - |
dc.date.accessioned | 2019-03-06T04:51:47Z | - |
dc.date.available | 2019-03-06T13:53:35Z | - |
dc.date.issued | 2018-10-23 | - |
dc.identifier.citation | BMC Nephrology, 19(1):292 | ko_KR |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/146856 | - |
dc.description.abstract | Backgrounds
Knowledge on cross-talk between the heart and kidney has been established by basic and clinical research. Nevertheless, the effects of systolic and diastolic heart dysfunctions on the development of acute kidney injury (AKI) and end-stage renal disease (ESRD) remain unresolved in hospitalized patients. Methods A total of 1327 hospitalized patients who had baseline transthoracic echocardiography performed were retrospectively analyzed. Patients were categorized by the quartiles of ejection fraction (EF) and the ratio of the early transmitral blood flow velocity to early diastolic velocity of the mitral annulus (E/e). The odds ratios (ORs) for AKI and the hazard ratios (HRs) for ESRD were calculated after adjustment of multiple covariates. Results During hospital admission, AKI occurred in 210 (15.8%) patients. The lowest quartile of EF was associated with a risk of AKI (OR, 1.60 [1.07–2.41]) and the highest quartile of E/e was associated with a risk of AKI (OR, 1.90 [1.26–2.41]). When two echocardiographic parameters were combined, patients with a low EF (first to second quartiles) and high E/e (fourth quartile) showed the highest OR for AKI (OR, 2.27 [1.49–3.45]) compared with the counterpart patients. When the risk of ESRD was evaluated, E/e, but not EF, was a significant parameter of high risk (fourth vs. first quartiles: HR, 4.13 [1.17–14.64]). Conclusions Baseline systolic and diastolic dysfunction is related to subsequent risks of AKI and ESRD in hospitalized patients. Monitoring of these parameters may be a useful strategy to predict the risk of these adverse events in the kidney. | ko_KR |
dc.description.sponsorship | This work was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03031642), which had neither role in the study design, nor in data collection, analysis, interpretation and nor in manuscript writing. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Acute kidney injury | ko_KR |
dc.subject | Echocardiography | ko_KR |
dc.subject | End-stage renal disease | ko_KR |
dc.subject | Diastolic dysfunction | ko_KR |
dc.subject | Systolic dysfunction | ko_KR |
dc.title | Systolic and diastolic dysfunction affects kidney outcomes in hospitalized patients | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최재신 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 진호준 | - |
dc.contributor.AlternativeAuthor | 나기영 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 김세중 | - |
dc.contributor.AlternativeAuthor | 한승석 | - |
dc.identifier.doi | 10.1186/s12882-018-1103-2 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-10-28T15:08:23Z | - |
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