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Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang R | - |
dc.contributor.author | Kwon, Sun Woo | - |
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Kaya, Pelin | - |
dc.contributor.author | Kim, Jong Min | - |
dc.contributor.author | Ahn, Changhwan | - |
dc.contributor.author | Jung, Eui-Man | - |
dc.contributor.author | Lee, Geun-Shik | - |
dc.contributor.author | An, Beum-Soo | - |
dc.contributor.author | Jeung, Eui-Bae | - |
dc.contributor.author | Park, Bae-keun | - |
dc.contributor.author | Hong, Eui-Ju | - |
dc.date.accessioned | 2019-03-13T04:59:02Z | - |
dc.date.available | 2020-01-15T13:54:14Z | - |
dc.date.issued | 2019-01-03 | - |
dc.identifier.citation | BMC Cancer, 19(1):6 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/147079 | - |
dc.description.abstract | Background
Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels. As a soybean-isoflavone product, genistein has estrogenic activity in various reproductive tissues, because it mimics 17β-estradiol and binds the estrogen receptor. Though genistein is a known liver cancer suppressor, its effects have not been studies in long-term experiment, where genistein is fed to a female animal model of HCC. Methods Mice were treated with diethylnitrosamine (DEN) to induce HCC at 2 weeks of age and fed with supplemental genistein for 5 months, from 40 to 62 weeks of age. Results The dietary intake of genistein decreased the incidence of HCC and suppressed HCC development. Genistein induced phospho-AMPK in total liver extracts, Hep3B cells, and Raw 264.7 cells, and phospho-AMPK promoted apoptosis in liver and Hep3B cells. Moreover, phospho-AMPK down-regulated pro-inflammatory responses and ameliorated liver damage. A suppressed pro-inflammatory response with increased mitochondrial respiration was concomitantly observed after genistein treatment. Conclusions Genistein-mediated AMPK activation increases hepatocyte apoptosis through energy-dependent caspase pathways, suppresses the inflammatory response in resident liver macrophages by increased cellular respiration, and consequently inhibits the initiation and progression of HCC. | ko_KR |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01060335 to E.-J.H.). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | HCC | ko_KR |
dc.subject | Genistein | ko_KR |
dc.subject | AMPK | ko_KR |
dc.subject | Inflammation | ko_KR |
dc.subject | Apoptosis | ko_KR |
dc.subject | Phytoestrogen | ko_KR |
dc.title | Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 권순우 | - |
dc.contributor.AlternativeAuthor | 이용호 | - |
dc.contributor.AlternativeAuthor | 김종민 | - |
dc.contributor.AlternativeAuthor | 안창환 | - |
dc.contributor.AlternativeAuthor | 정위만 | - |
dc.contributor.AlternativeAuthor | 이근식 | - |
dc.contributor.AlternativeAuthor | 안범수 | - |
dc.contributor.AlternativeAuthor | 정위배 | - |
dc.contributor.AlternativeAuthor | 박배근 | - |
dc.contributor.AlternativeAuthor | 홍의주 | - |
dc.identifier.doi | 10.1186/s12885-018-5222-8 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-01-06T04:14:23Z | - |
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