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Primary renal well-differentiated neuroendocrine tumors: report of six cases with an emphasis on the Ki-67 index and mitosis

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dc.contributor.authorKim, Bohyun-
dc.contributor.authorKim, Han-Seong-
dc.contributor.authorMoon, Kyung Chul-
dc.date.accessioned2019-03-18T08:46:30Z-
dc.date.available2019-03-18T18:01:23Z-
dc.date.issued2019-02-07-
dc.identifier.citationDiagnostic Pathology. 2019 Feb 07;14(1):12ko_KR
dc.identifier.issn1746-1596-
dc.identifier.urihttps://hdl.handle.net/10371/147176-
dc.description.abstractBackground
Primary renal well-differentiated neuroendocrine tumors (WDNETs) also called carcinoid and atypical carcinoid are extremely rare, and little is known about parameters that may predict prognosis at diagnosis.

Methods
Six cases of primary renal WDNET were collected. After reviewing slides stained with hematoxylin and eosin, proportions of each growth pattern were determined. Synaptophysin, chromogranin, CD56, and Ki-67 immunostaining and Ki-67 morphometric analysis were performed.

Results
Patients included three female and three males, mean age was 53.3 years. The mean tumor size was 4.5 cm, three cases were greater than 5 cm. At the time of initial surgery, lymph node and/or distant metastasis was confirmed in two cases. In a third case, no metastasis was initially found, but lymph node metastasis was identified during follow-up. The remaining three cases did not exhibit metastasis. Histopathologically, the renal WDNETs were primarily composed of ribbon-like and sheet-like growth patterns. Most of the tumors were diffusely positive for neuroendocrine markers. Mitotic count was high (≥2/10HPF) in cases with lymph node or distant metastasis but was low (< 2/10HPF) in non-metastatic cases. Furthermore, the Ki-67 index was also higher (≥3%) in the cases with metastases than in cases without metastasis.

Conclusion
Three out of the six primary renal WDNETs demonstrated aggressive behavior and exhibited increased mitotic counts and Ki-67 indices. These results suggest that mitosis and the Ki-67 index could be used as prognostic indicators for renal WDNET.
ko_KR
dc.description.sponsorshipThis work was supported by grant 04–2016-0460 from the Seoul National University Hospital Research Fund.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectRenal well-differentiated neuroendocrine tumorko_KR
dc.subjectKi-67ko_KR
dc.subjectCarcinoid tumorko_KR
dc.subjectMitosisko_KR
dc.subjectGradeko_KR
dc.subjectPrognosisko_KR
dc.titlePrimary renal well-differentiated neuroendocrine tumors: report of six cases with an emphasis on the Ki-67 index and mitosisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김보현-
dc.contributor.AlternativeAuthor김한성-
dc.contributor.AlternativeAuthor문경철-
dc.identifier.doi10.1186/s13000-019-0791-7-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-02-10T04:21:25Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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