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General review of titanium toxicity

DC Field Value Language
dc.contributor.authorKim, Kyeong Tae-
dc.contributor.authorEo, Mi Young-
dc.contributor.authorNguyen, Truc Thi Hoang-
dc.contributor.authorKim, Soung Min-
dc.date.accessioned2019-03-21T05:46:33Z-
dc.date.available2019-03-21T14:47:08Z-
dc.date.issued2019-03-11-
dc.identifier.citationInternational Journal of Implant Dentistry. 2019 Mar 11;5(1):10ko_KR
dc.identifier.issn2198-4034-
dc.identifier.urihttps://hdl.handle.net/10371/147207-
dc.description.abstractBackground
Titanium is a commonly used inert bio-implant material within the medical and dental fields. Although the use of titanium is thought to be safe with a high success rate, in some cases, there are rare reports of problems caused by titanium. In most of these problematic reports, only individual reports are dominant and comprehensive reporting has not been performed. This comprehensive article has been prepared to review the toxicity of titanium materials within the medical and dental fields.

Methods
We used online searching tools including MEDLINE (PubMed), Embase, Cochrane Library, and Google Scholar by combining keywords such as titanium implant toxicity, titanium implant corrosion, titanium implant allergy, and yellow nail syndrome. Recently updated data has been collected and compiled into one of four categories: the toxicity of titanium, the toxicity of titanium alloys, the toxicity of titanium implants, and diseases related to titanium.

Results
Recent studies with regard to titanium toxicity have been increasing and have now expanded to the medical field in addition to the fields of environmental research and basic science. Problems that may arise in titanium-based dental implants include the generation of titanium and titanium alloy particles and ions deposited into surrounding tissues due to the corrosion and wear of implants, resulting in bone loss due to inflammatory reactions, which may lead to osseointegration failure of the dental implant. These titanium ions and particles are systemically deposited and can lead to toxic reactions in other tissues such as yellow nail syndrome. Additionally, implant failure and allergic reactions can occur due to hypersensitivity reactions. Zirconia implants can be considered as an alternative; however, limitations still exist due to a lack of long-term clinical data.

Conclusions
Clinicians should pay attention to the use of titanium dental implants and need to be aware of the problems that may arise from the use of titanium implants and should be able to diagnose them, in spite of very rare occurrence. Within the limitation of this study, it was suggested that we should be aware the rare problems of titanium toxicity.
ko_KR
dc.description.sponsorshipThere is no funding related to this article.ko_KR
dc.language.isoenko_KR
dc.publisherSpringer Openko_KR
dc.subjectTitanium toxicityko_KR
dc.subjectTitanium dental implant toxicityko_KR
dc.subjectTitanium allergyko_KR
dc.subjectTitanium corrosionko_KR
dc.subjectYellow nail syndromeko_KR
dc.titleGeneral review of titanium toxicityko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김경태-
dc.contributor.AlternativeAuthor오미영-
dc.contributor.AlternativeAuthor김성민-
dc.identifier.doi10.1186/s40729-019-0162-x-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-03-17T04:21:53Z-
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